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钯（II）与二吡啶并[3,2 - d:2',3'- f]喹喔啉/二吡啶并[3,2 - a:2',3'- c](6,7,8,9 - 四氢)吩嗪和4 - 甲苯磺酰基 - L - 氨基酸二价阴离子的混合配体配合物的合成、表征及细胞毒性

Synthesis, characterization, cytotoxicity of mixed ligand complexes of palladium(II) with dipyrido[3,2-d:2',3'-f]quinoxaline/dipyrido[3,2-a:2',3'-c](6,7,8,9-tetrahydro)phenazine and 4-toluensulfonyl-L-amino acid dianion.

作者信息

Ma Lili, Ge Kun, Zhang Ran, Fu Wentao, Li Shenghui, Wang Shuxiang, Zhou Guoqiang, Qin Xinying, Zhang Jinchao

机构信息

College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China.

College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China.

出版信息

Eur J Med Chem. 2014 Nov 24;87:624-30. doi: 10.1016/j.ejmech.2014.10.002. Epub 2014 Oct 7.

DOI:10.1016/j.ejmech.2014.10.002
PMID:25299684
Abstract

Ten novel palladium(II) complexes with dipyrido[3,2-d:2',3'-f]quinoxaline (Dpq)/dipyrido3,2-a:2',3'-cphenazine (Dpqc) and 4-toluensulfonyl-L-amino acid dianion, [Pd(Dpq)(TsvalNO)]·H2O (1a), [Pd(Dpq)(TsileNO)]·H2O (1b), [Pd(Dpq)(TsserNO)] (1c), [Pd(Dpq)(TsthrNO)]·1.5H2O (1d), [Pd(Dpq)(TsleuNO)]·0.5H2O (1e), [Pd(Dpq)(TspheNO)] (1f), [Pd(Dpqc)(TsvalNO)] (2a), [Pd(Dpqc)(TsileNO)] (2b), [Pd(Dpqc)(TsserNO)]·H2O (2c) and [Pd(Dpqc)(TsthrNO)]·0.5H2O (2d) have been synthesized and characterized by elemental analysis, IR, UV, (1)H NMR and mass spectrometry techniques. Crystal structure of the complex 1f has been determined by X-ray diffraction. The cytotoxicity was tested by MTT assay. The results indicated that the complexes 1a and 2a showed better cytotoxicity than cisplatin against MCF-7. The complex 1e had higher cytotoxicity than cisplatin against K562. Both the N donating ligands and the amino acid have important effects on the cytotoxicity.

摘要

合成了十种新型钯（II）配合物，其配体为二吡啶并[3,2 - d:2',3'- f]喹喔啉（Dpq）/二吡啶并[3,2 - a:2',3'- c](6,7,8,9 - 四氢)吩嗪（Dpqc）和4 - 甲苯磺酰基 - L - 氨基酸二价阴离子，分别为[Pd(Dpq)(TsvalNO)]·H₂O（1a）、[Pd(Dpq)(TsileNO)]·H₂O（1b）、[Pd(Dpq)(TsserNO)]（1c）、[Pd(Dpq)(TsthrNO)]·1.5H₂O（1d）、[Pd(Dpq)(TsleuNO)]·0.5H₂O（1e）、[Pd(Dpq)(TspheNO)]（1f）、[Pd(Dpqc)(TsvalNO)]（2a）、[Pd(Dpqc)(TsileNO)]（2b）、[Pd(Dpqc)(TsserNO)]·H₂O（2c）和[Pd(Dpqc)(TsthrNO)]·0.5H₂O（2d），并通过元素分析、红外光谱、紫外光谱、¹H NMR和质谱技术对其进行了表征。配合物1f的晶体结构已通过X射线衍射确定。通过MTT法测试了细胞毒性。结果表明，配合物1a和2a对MCF - 7的细胞毒性比顺铂更好。配合物1e对K562的细胞毒性比顺铂更高。含氮供体配体和氨基酸对细胞毒性都有重要影响。

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