钯（II）与芳香二亚胺和 4-甲苯磺酰基-L-氨基酸二阴离子配合物的合成、表征及细胞毒性。
Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl-L-amino acid dianion.
机构信息
College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China.
出版信息
Eur J Med Chem. 2010 Nov;45(11):5337-44. doi: 10.1016/j.ejmech.2010.08.058.
Eight new palladium(II) complexes (1a-2d) with 4-toluenesulfonyl-l-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV, (1)H NMR, (13)C NMR and mass spectra techniques. Crystal structure of the complex (2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate that the complexes (1a-2d) have selectivity against tested carcinoma cell lines. The complex (2c) has the best cytotoxicity among the eight complexes, moreover its cytotoxicity is better than that of cisplatin against BGC-823, Bel-7402 and KB cell lines. It suggests that both aromatic diimine and 4-toluenesulfonyl-L-amino acid have important effect on cytotoxicity.
已合成了八个新的钯（II）配合物（1a-2d），它们具有 4-甲苯磺酰基-L-氨基酸二阴离子和二亚胺（bipy 和 phen），并通过元素分析、IR、UV、（1）H NMR、（13）C NMR 和质谱技术进行了表征。通过 X 射线衍射分析确定了配合物（2d）的晶体结构。通过 MTT 和 SRB 测定法测试了细胞毒性。结果表明，这些配合物（1a-2d）对测试的癌细胞系具有选择性。在这八个配合物中，配合物（2c）具有最佳的细胞毒性，而且其细胞毒性优于顺铂对 BGC-823、Bel-7402 和 KB 细胞系的细胞毒性。这表明芳香二亚胺和 4-甲苯磺酰基-L-氨基酸对细胞毒性都有重要影响。
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