线粒体在真菌衰老中的作用。

The role of mitochondria in fungal aging.

机构信息

Institute of Molecular Biosciences and Cluster of Excellence Frankfurt Macromolecular Complexes, Department of Biosciences, J.W. Goethe University, Frankfurt, Germany.

出版信息

Curr Opin Microbiol. 2014 Dec;22:1-7. doi: 10.1016/j.mib.2014.09.007. Epub 2014 Oct 6.

DOI:10.1016/j.mib.2014.09.007

PMID:25299751

Abstract

Time-dependent impairments of mitochondrial function play a key role in biological aging. Work on fungal aging models has been instrumental in unraveling basic mechanisms leading to mitochondrial dysfunction and the identification of different pathways active in keeping mitochondria 'healthy' over time. Pathways including those involved in reactive oxygen scavenging, repair of damage, proteostasis, mitochondrial dynamics, and biogenesis, are interconnected and part of a complex quality control system. The individual components of this network are limited in capacity. However, if the capacity of one pathway is overwhelmed, another one may be activated. The mechanisms controlling the underlying cross-talk are poorly understood and subject of intensive investigation.

摘要

线粒体功能的时变损伤在生物衰老中起着关键作用。真菌衰老模型的研究对于揭示导致线粒体功能障碍的基本机制以及鉴定不同的途径在维持线粒体随时间“健康”方面发挥了重要作用。这些途径包括涉及活性氧清除、损伤修复、蛋白稳态、线粒体动力学和生物发生的途径，它们相互关联，是一个复杂的质量控制系统的一部分。该网络的各个组成部分的容量是有限的。然而，如果一个途径的容量被超过，另一个途径可能会被激活。控制这种潜在串扰的机制还了解甚少，是一个深入研究的课题。