Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Bower Building, University of Glasgow, Glasgow G12 8QQ, UK.
Curr Opin Struct Biol. 2014 Dec;29:52-7. doi: 10.1016/j.sbi.2014.09.004. Epub 2014 Oct 7.
UVR8 is a UV-B photoreceptor that employs specific tryptophans in its primary sequence as chromophores in photoreception. UV-B absorption causes dissociation of the dimeric photoreceptor by neutralizing interactions between monomers. The monomeric form initiates signalling through interaction with the COP1 protein, leading to transcriptional responses. This article discusses the structural basis of UVR8 function, highlighting recent research on the mechanism of photoreception and on interactions with other proteins involved in signalling and regulation.
UVR8 是一种 UV-B 光受体，其一级序列中特定的色氨酸作为光受体中的生色团。UV-B 吸收通过中和单体之间的相互作用导致二聚体光受体的解离。单体形式通过与 COP1 蛋白相互作用起始信号转导，导致转录反应。本文讨论了 UVR8 功能的结构基础，重点介绍了光受体机制以及与参与信号转导和调节的其他蛋白质相互作用的最新研究。
