Pryce D W, Irvine D, English J S, Rycroft R J
St. John's Hospital for Diseases of the Skin, London, UK.
Contact Dermatitis. 1989 Jul;21(1):28-35. doi: 10.1111/j.1600-0536.1989.tb04681.x.
A pilot follow-up study of patients with soluble oil dermatitis was designed to investigate the effects on prognosis of aetiology and of stopping working with soluble oils. A questionnaire was sent to 121 machine operators who had been diagnosed over a 5-year period. Life table analysis of the 100 replies (83%) revealed a poor prognosis both for those who had continued to work with soluble oils and for those who had stopped. 78% (95% confidence intervals: 63%-94%) of those who continued to work with soluble oils had not healed 2 years after diagnosis. 70% (95% confidence intervals: 56%-83%) of those who stopped working with soluble oil had not healed 2 years after discontinuing contact. Both groups were divided into 4 subgroups with different combinations of aetiological components: allergic and endogenous, non-allergic and endogenous, allergic and non-endogenous, non-allergic and non-endogenous. No significant difference in outcome emerged in either the discontinued contact group or the continued contact group between any aetiological subgroups. Patients who discontinued contact with soluble oils fell into 2 groups: those who healed rapidly and those who developed a chronic dermatitis. 11 of the 15 patients who had healed after 2 years had done so within the first 3 months following cessation of contact. No factor could be identified to distinguish those with the more favourable prognosis. The implications of this study for the management of soluble oil dermatitis are discussed.
一项针对可溶性油皮炎患者的试点随访研究旨在调查病因以及停止接触可溶性油对预后的影响。向在5年期间被诊断出患有该病的121名机器操作员发送了调查问卷。对100份回复（83%）进行生命表分析后发现，继续接触可溶性油的患者和已经停止接触的患者预后都很差。在诊断后2年，继续接触可溶性油的患者中有78%（95%置信区间：63%-94%）未痊愈。停止接触可溶性油的患者在停止接触后2年中有70%（95%置信区间：56%-83%）未痊愈。两组患者根据病因成分的不同组合被分为4个亚组：过敏性和内源性、非过敏性和内源性、过敏性和非内源性、非过敏性和非内源性。在停止接触组或继续接触组中，任何病因亚组之间的预后均无显著差异。停止接触可溶性油的患者分为两组：一组愈合迅速，另一组发展为慢性皮炎。在停止接触后2年内痊愈的15名患者中，有11名是在停止接触后的前3个月内痊愈的。无法确定任何因素来区分预后较好的患者。本文讨论了该研究对可溶性油皮炎治疗的意义。
