Pilger C, Nethercott J R, Weksberg F
Contact Dermatitis. 1986 Apr;14(4):201-4. doi: 10.1111/j.1600-0536.1986.tb01224.x.
3 cases of contact allergy due to the biocides 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one are reported. 2 workers exposed to a soluble oil containing these 2 biocides experienced allergic contact dermatitis from them. The 3rd case was that of the chemist who separated the 2 materials for the execution of this investigation. These compounds are chemically related to the biologically active components of Ectimar, Skane M-8 and Proxel CRL. Further instances of contact allergy due to these and related compounds are likely because of the apparently increasing use of such substances as antimicrobial agents in various commercial products.
报告了3例因杀生剂5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮引起的接触性过敏病例。2名接触含有这两种杀生剂的可溶性油的工人因此患上了过敏性接触性皮炎。第3例是为进行这项调查而分离这两种物质的化学家。这些化合物在化学上与Ectimar、Skane M-8和Proxel CRL的生物活性成分有关。由于此类物质作为抗菌剂在各种商业产品中的使用明显增加，因这些及相关化合物引起的接触性过敏可能会有更多病例。
