Roggero Paola, Giannì Maria Lorella, Forzenigo Laura, Tondolo Tania, Taroni Francesca, Liotto Nadia, Piemontese Pasqua, Biondetti Pietro, Mosca Fabio
Neonatal Intensive Care Unit, Department of Clinical Science and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Neonatology. 2015;107(1):14-9. doi: 10.1159/000364855. Epub 2014 Oct 4.
Preterm infants may be at risk for altered adiposity, a known risk factor for unfavorable metabolic and cardiovascular outcomes.
The aim was to compare body composition (total body fat mass (FM), subcutaneous and intra-abdominal adipose tissue (AT)) between infants born preterm and at term.
We conducted an observational, cross-sectional study that involved 50 infants born preterm free from major co-morbidities and 34 term healthy breastfed infants. Anthropometric measurements, body composition (total body FM, subcutaneous and intra-abdominal AT) were assessed at 40-42 weeks postconceptional age for preterm infants and within 15 days of birth for term infants. Total body FM was assessed by an air displacement plethysmography system and subcutaneous abdominal and intra-abdominal AT were assessed by magnetic resonance imaging using a commercially available software program.
Compared to term infants, mean (SD) total body FM (g) (636.7 (247) vs. 418.4 (253), p < 0.0001) and mean (SD) subcutaneous abdominal AT (g) (123 (36) vs. 98.9 (22), p < 0.001) were significantly higher in preterm infants but mean (SD) fat-free mass (g) (2,530 (420) vs. 2,965 (389), p < 0.0001) and mean (SD) intra-abdominal AT (10.9 (5.2) vs. 18.2 (13.2), p = 0.001) were significantly lower.
In the absence of severe illness during the hospital stay, prematurity, although associated with increased total body FM, does not appear to be associated with a relative increase in intra-abdominal AT compared to term infants.
早产婴儿可能存在肥胖改变的风险，而肥胖是已知的不良代谢和心血管结局的风险因素。
旨在比较早产和足月出生婴儿的身体成分（全身脂肪量（FM）、皮下和腹部内脏脂肪组织（AT））。
我们进行了一项观察性横断面研究，纳入50例无主要合并症的早产婴儿和34例足月健康母乳喂养婴儿。对早产婴儿在孕龄40 - 42周时进行人体测量和身体成分评估（全身FM、皮下和腹部内脏AT），对足月婴儿在出生后15天内进行评估。全身FM通过空气置换体积描记系统评估，皮下腹部和腹部内脏AT通过磁共振成像使用商用软件程序评估。
与足月婴儿相比，早产婴儿的平均（标准差）全身FM（克）（636.7（247）对418.4（253），p < 0.0001）和平均（标准差）皮下腹部AT（克）（123（36）对98.9（22），p < 0.001）显著更高，但平均（标准差）去脂体重（克）（2530（420）对2965（389），p < 0.0001）和平均（标准差）腹部内脏AT（10.9（5.2）对18.2（13.2），p = 0.001）显著更低。
在住院期间无严重疾病的情况下，早产虽然与全身FM增加有关，但与足月婴儿相比，腹部内脏AT似乎并未相对增加。
