Sercarz E, Oki A, Gammon G
Department of Microbiology, University of California, Los Angeles 90024.
Immunol Suppl. 1989;2:9-14; discussion 15.
The period of intellectual history of immunology that we wish to treat began some 30 years ago, in 1958, when the features of immune tolerance had already been described (Billingham, Brent & Medawar, 1953), but mechanisms remained difficult to fathom. The subsequent 30 years in quest of the key(s) to tolerance can be roughly divided into the pre-T-cell suppression half, and the years from 1973 to 1988 in which the major rival to ideas of clonal deletion or abortion has been the T-suppressor cell.
我们想要探讨的免疫学思想史时期始于大约30年前，即1958年，当时免疫耐受的特征已被描述（比林厄姆、布伦特和梅达沃，1953年），但其机制仍难以理解。在随后探寻耐受关键因素的30年中，大致可分为前T细胞抑制阶段，以及从1973年到1988年这一阶段，在此期间，克隆缺失或流产理论的主要竞争对手是T抑制细胞。
