Kong Y Y, Eto M, Omoto K, Umesue M, Hashimoto A, Nomoto K
Department of Immunology, Medical Institute of Bioregulation, Fukuoka, Japan.
J Immunol. 1996 Dec 15;157(12):5284-9.
Whether regulatory T cells could suppress the immune responses to an unrelated Ag and could induce tolerance to that Ag was investigated. In female B6 (I-Ab) mice tolerized to MHC class II I-Abm12 (bm12) alloantigen by cyclophosphamide-induced system, regulatory T cells specific for bm12 Ag were induced. These regulatory T cells suppressed in vivo immune responses to an unrelated Ag (male Ag) that was co-expressed with bm12 Ag on the same graft. However, the immune responses to male Ag suppressed by regulatory T cells were reverted by immunization with male Ag alone, indicating regulatory T cells suppressed the induction of immune responses to the unrelated Ag co-expressed with suppressogenic determinant, but did not inactivate T cells specific for that third Ag, such as clonal anergy or deletion. These results provided that minor Ag adjacent to major Ag, even if they were expressed on the professional APC, could be suppressed in the periphery, and the responses to those minor Ag could be activated when the suppression mechanism was abrogated or ineffective.
研究了调节性T细胞是否能够抑制对无关抗原的免疫反应并诱导对该抗原的耐受性。在通过环磷酰胺诱导系统耐受MHC II类I-Abm12（bm12）同种异体抗原的雌性B6（I-Ab）小鼠中，诱导了对bm12抗原有特异性的调节性T细胞。这些调节性T细胞在体内抑制了对与bm12抗原在同一移植物上共表达的无关抗原（雄性抗原）的免疫反应。然而，单独用雄性抗原免疫可恢复被调节性T细胞抑制的对雄性抗原的免疫反应，这表明调节性T细胞抑制了对与抑制性决定簇共表达的无关抗原的免疫反应的诱导，但并未使针对该第三种抗原的T细胞失活，如克隆无能或克隆缺失。这些结果表明，即使主要抗原附近的次要抗原在专职抗原呈递细胞上表达，它们在外周也可能被抑制，并且当抑制机制被废除或无效时，对这些次要抗原的反应可能被激活。
