Kaur Sukhraj, Mahajan Mridula, Bal B S
Lecturer, Department of Biochemistry, Government Medical College , Amritsar, India .
Professor and Head, Department of Biochemistry, Government Medical College , Amritsar, India .
J Clin Diagn Res. 2014 Aug;8(8):CC14-8. doi: 10.7860/JCDR/2014/10198.4701. Epub 2014 Aug 20.
Insulin resistance a physiological condition is marked by hyperglycemia and failure of cells to respond to normal action thus hyperinsulinemia. It is prevalent in individuals having genetic predisposition and family history of type 2 diabetes mellitus. Physically inactive individuals having sedentary life style are also at a risk of developing insulin resistance.
The present study was planned to observe the prevalence of insulin resistance or pre diabetes in various age groups of North West Punjabi population.
A total of 400 families comprising of 1159 offsprings of diabetic patients and siblings amongst each were included in the present study. All these 400 families had history of type 2 diabetes mellitus in the present or past generation. Written consent was taken from the head of the family for inclusion in the study. Fasting samples were collected and analysed for Glucose, Glycosylated Hb, complete lipid profile, Insulin and c-peptide. Body mass index, waist hip ratio and HOMA-IR were calculated. Comparison of mean of various parameters was done using student t-test. Analysis of variance (ANOVA) was applied for comparison between groups followed by Bonferroni post hoc analysis. Pearson's correlation method was used for quantitative variables. Statistical significance was defined as p<0.05 (two tailed).
Prevalence of impaired fasting glucose both in males and females increased with advancing age. Hyperglycemia along with hyperinsulinemia, hypercholesterolemia and hypertriglyceridemia was observed in individuals having impaired fasting glucose. Individuals belonging to age group of >18-35 years were more prone to insulin resistance as compared to other age groups.
Insulin resistance at a young age of 18-35 years predisposes these individuals to coronary events. Females in reproductive years are more prone to insulin resistance or pre diabetes as compared to males of the same age group.
胰岛素抵抗是一种生理状况，其特征为高血糖以及细胞对正常作用无反应，进而导致高胰岛素血症。它在有2型糖尿病遗传易感性和家族病史的个体中普遍存在。生活方式久坐不动、缺乏身体活动的个体也有发生胰岛素抵抗的风险。
本研究旨在观察旁遮普邦西北部不同年龄组人群中胰岛素抵抗或糖尿病前期的患病率。
本研究共纳入400个家庭，这些家庭中有1159名糖尿病患者的后代及兄弟姐妹。所有这400个家庭在当前或上一代均有2型糖尿病病史。已获得家族户主的书面同意以纳入本研究。采集空腹样本并分析血糖、糖化血红蛋白、完整血脂谱、胰岛素和C肽。计算体重指数、腰臀比和稳态模型评估胰岛素抵抗（HOMA-IR）。使用学生t检验比较各项参数的均值。采用方差分析（ANOVA）进行组间比较，随后进行Bonferroni事后分析。使用Pearson相关方法分析定量变量。统计学显著性定义为p<0.05（双侧）。
男性和女性空腹血糖受损的患病率均随年龄增长而增加。在空腹血糖受损的个体中观察到高血糖以及高胰岛素血症、高胆固醇血症和高甘油三酯血症。与其他年龄组相比，年龄在>18 - 35岁的个体更易发生胰岛素抵抗。
18 - 35岁的年轻人出现胰岛素抵抗会使这些个体易患冠心病事件。与同年龄组男性相比，育龄期女性更易发生胰岛素抵抗或糖尿病前期。
