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C肽在不同组织中的促炎作用。

Proinflammatory effects of C-Peptide in different tissues.

作者信息

Vasic Dusica, Walcher Daniel

机构信息

Department of Internal Medicine II, Cardiology, University of Ulm, Albert-Einstein-Alle 23, 89081 Ulm, Germany.

出版信息

Int J Inflam. 2012;2012:932725. doi: 10.1155/2012/932725. Epub 2012 Jun 11.

DOI:10.1155/2012/932725
PMID:22762010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3384941/
Abstract

Atherosclerosis is well known as an inflammatory disease that can lead to clinical complications such as heart attack or stroke. C-peptide as a cleavage product of proinsulin is in the last few decades known as an active peptide with a number of different effects on microvascular and macrovascular complications in type 2 diabetic patients. Patients with insulin resistance and early type 2 diabetes show elevated levels of C-peptide in blood. Several last findings demonstrated deposition of C-peptide in the vessel wall in ApoE-deficient mice and induction of local inflammation. Besides that, C-peptide has proliferative effects on human mesangial cells. This review discusses recently published proinflammatory effects of C-peptide in different tissues.

摘要

动脉粥样硬化是一种众所周知的炎症性疾病，可导致心脏病发作或中风等临床并发症。C肽作为胰岛素原的裂解产物，在过去几十年中被认为是一种活性肽，对2型糖尿病患者的微血管和大血管并发症有多种不同影响。胰岛素抵抗和早期2型糖尿病患者血液中的C肽水平升高。最近的一些研究结果表明，C肽在载脂蛋白E缺乏小鼠的血管壁中沉积，并诱导局部炎症。除此之外，C肽对人系膜细胞有增殖作用。本文综述了最近发表的C肽在不同组织中的促炎作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a16/3384941/7e8580f18b80/IJI2012-932725.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a16/3384941/5ec3d110cf8f/IJI2012-932725.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a16/3384941/7e8580f18b80/IJI2012-932725.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a16/3384941/5ec3d110cf8f/IJI2012-932725.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a16/3384941/7e8580f18b80/IJI2012-932725.002.jpg

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本文引用的文献

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Mol Cell Endocrinol. 2012 Apr 4;351(2):337-41. doi: 10.1016/j.mce.2012.01.011. Epub 2012 Jan 16.
2
C-peptide promotes lesion development in a mouse model of arteriosclerosis.C 肽促进动脉粥样硬化小鼠模型的病变发展。
J Cell Mol Med. 2012 Apr;16(4):927-35. doi: 10.1111/j.1582-4934.2011.01365.x.
3
Proteinuria in diabetes: bystander or pathway to cardiorenal disease?
单独使用C肽或联合烟酰胺对小鼠胰岛胰岛素水平的影响。
Malays J Med Sci. 2016 Jan;23(1):15-21.
4
ProInflam: a webserver for the prediction of proinflammatory antigenicity of peptides and proteins.ProInflam：一个用于预测肽和蛋白质促炎抗原性的网络服务器。
J Transl Med. 2016 Jun 14;14(1):178. doi: 10.1186/s12967-016-0928-3.
5
C-Peptide Is Independently Associated with an Increased Risk of Coronary Artery Disease in T2DM Subjects: A Cross-Sectional Study.C肽与2型糖尿病患者冠状动脉疾病风险增加独立相关：一项横断面研究。
PLoS One. 2015 Jun 22;10(6):e0127112. doi: 10.1371/journal.pone.0127112. eCollection 2015.
6
C-peptide as a Therapy for Kidney Disease: A Systematic Review and Meta-Analysis.C肽作为一种肾脏疾病治疗方法：系统评价与荟萃分析
PLoS One. 2015 May 20;10(5):e0127439. doi: 10.1371/journal.pone.0127439. eCollection 2015.
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Malays J Med Sci. 2014 Jul;21(4):12-7.
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