Sabio José Mario, Sánchez-Berná Isabel, Martinez-Bordonado Josefina, Vargas-Hitos José Antonio, Navarrete-Navarrete Nuria, Expósito Ruíz Manuela, Jiménez-Alonso Juan
University Hospital Virgen de las Nieves, Granada, Spain.
Arthritis Care Res (Hoboken). 2015 Apr;67(4):554-62. doi: 10.1002/acr.22493.
To compare the presence of subclinical atherosclerosis measured by means of pulse wave velocity (PWV) in women with primary Sjögren's syndrome (SS) versus a healthy age- and sex-matched control group, and to identify factors independently associated with PWV in primary SS.
Forty-four women with primary SS and 78 age-matched healthy women without overt cardiovascular (CV) diseases were assessed for traditional and nontraditional CV risk factors. PWV was also performed. A linear regression analysis was used to identify factors independently associated with PWV in primary SS.
Women with primary SS had significantly higher PWV than controls (P = 0.030), and the frequency of increased PWV was significantly higher in this group (25% versus 8%; P = 0.013). The proportion of patients ages ≤50 years (ratio 4.6) with increased PWV was almost 2-fold higher than those ages >50 years (ratio 2.4) with respect to controls. Positivity for anti-SSB was more frequent in patients with normal PWV than in those with increased PWV (61% versus 18%; P = 0.034). Women with primary SS and increased PWV had lower levels of 25-hydroxyvitamin D (25[OH]D; P = 0.047) than primary SS patients with normal PWV. In addition, 25(OH)D levels tended to correlate inversely with PWV in women with primary SS (P = 0.067), but not in controls (P = 0.97). In multivariate analysis, the Framingham Risk Score (FRS) and Sjögren's Syndrome Damage Index emerged as factors independently correlated with PWV.
Women with primary SS had higher PWV than controls, but a similar FRS. The FRS and chronic damage were found to be independently associated with PWV.
比较通过脉搏波速度（PWV）测量的亚临床动脉粥样硬化在原发性干燥综合征（SS）女性患者与年龄和性别匹配的健康对照组中的情况，并确定原发性SS中与PWV独立相关的因素。
对44例原发性SS女性患者和78例年龄匹配、无明显心血管（CV）疾病的健康女性进行传统和非传统CV危险因素评估。同时测量PWV。采用线性回归分析确定原发性SS中与PWV独立相关的因素。
原发性SS女性患者的PWV显著高于对照组（P = 0.030），且该组PWV升高的频率显著更高（25%对8%；P = 0.013）。年龄≤50岁（比例4.6）的PWV升高患者比例相对于对照组几乎是年龄>50岁（比例2.4）患者的2倍。抗SSB阳性在PWV正常的患者中比在PWV升高的患者中更常见（61%对18%；P = 0.034）。原发性SS且PWV升高的女性患者的25-羟维生素D（25[OH]D）水平低于PWV正常的原发性SS患者（P = 0.047）。此外，原发性SS女性患者中25(OH)D水平倾向于与PWV呈负相关（P = 0.067），但在对照组中无此相关性（P = 0.97）。多变量分析显示，弗明汉风险评分（FRS）和干燥综合征损伤指数是与PWV独立相关的因素。
原发性SS女性患者的PWV高于对照组，但FRS相似。FRS和慢性损伤被发现与PWV独立相关。
