抗胆碱能支气管扩张剂对黏液纤毛转运和气道分泌物的影响。

Effects of anticholinergic bronchodilators on mucociliary transport and airway secretion.

作者信息

Miyata T, Matsumoto N, Yuki H, Oda Y, Takahama K, Kai H

机构信息

Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.

出版信息

Jpn J Pharmacol. 1989 Sep;51(1):11-5. doi: 10.1254/jjp.51.11.

DOI:10.1254/jjp.51.11

PMID:2530378

Abstract

The effects of atropine, ipratropium and oxitropium on the mucociliary clearance were studied in pigeons and rabbits. The normal mucociliary transport (MCT) in pigeons was inhibited after the treatment by any of the three drugs at concentrations of 10(-4) to 10(-3) g/ml. These three drugs markedly inhibited eserine-induced MCT acceleration at a lower concentration than ACh-induced acceleration. The normal airway secretion was inhibited only by atropine in rabbits. The results indicate that neither oxitropium nor ipratropium depress the normal mucociliary clearance, but atropine may depress it under some conditions. Additionally, we suggest that these anticholinergic drugs might selectively affect the mucociliary transport modulated by endogenous ACh.

摘要

研究了阿托品、异丙托溴铵和氧托溴铵对鸽子和兔子黏液纤毛清除功能的影响。三种药物在浓度为10(-4)至10(-3) g/ml时处理后，均可抑制鸽子正常的黏液纤毛运输（MCT）。这三种药物在比乙酰胆碱诱导的加速作用更低的浓度下，就能显著抑制毒扁豆碱诱导的MCT加速。仅阿托品可抑制兔子正常的气道分泌。结果表明，氧托溴铵和异丙托溴铵均不会降低正常的黏液纤毛清除功能，但阿托品在某些情况下可能会降低该功能。此外，我们认为这些抗胆碱能药物可能会选择性地影响由内源性乙酰胆碱调节的黏液纤毛运输。