从人T细胞中克隆白细胞介素1受体。
Cloning the interleukin 1 receptor from human T cells.
作者信息
Sims J E, Acres R B, Grubin C E, McMahan C J, Wignall J M, March C J, Dower S K
机构信息
Immunex Corp., Seattle, WA 98101.
出版信息
Proc Natl Acad Sci U S A. 1989 Nov;86(22):8946-50. doi: 10.1073/pnas.86.22.8946.
Abstract
cDNA clones of the interleukin 1 (IL-1) receptor expressed in a human T-cell clone have been isolated by using a murine IL-1 receptor cDNA as a probe. The human and mouse receptors show a high degree of sequence conservation. Both are integral membrane proteins possessing a single membrane-spanning segment. Similar to the mouse receptor, the human IL-1 receptor contains a large cytoplasmic region and an extracellular, IL-1 binding portion composed of three immunoglobulin-like domains. When transfected into COS cells, the human IL-1 receptor cDNA clone leads to expression of two different affinity classes of receptors, with Ka values indistinguishable from those determined for IL-1 receptors in the original T-cell clone. An IL-1 receptor expressed in human dermal fibroblasts has also been cloned and sequenced and found to be identical to the IL-1 receptor expressed in T cells.
摘要
利用鼠白细胞介素1（IL-1）受体cDNA作为探针，已从一个人T细胞克隆中分离出了表达的IL-1受体的cDNA克隆。人和小鼠的受体显示出高度的序列保守性。两者都是具有单个跨膜区段的整合膜蛋白。与小鼠受体相似，人IL-1受体包含一个大的胞质区域和一个由三个免疫球蛋白样结构域组成的细胞外IL-1结合部分。当转染到COS细胞中时，人IL-1受体cDNA克隆导致两种不同亲和力类别的受体表达，其解离常数（Ka）值与在原始T细胞克隆中测定的IL-1受体的值无法区分。在人皮肤成纤维细胞中表达的IL-1受体也已被克隆和测序，发现与在T细胞中表达的IL-1受体相同。
相似文献
1
Cloning the interleukin 1 receptor from human T cells.从人T细胞中克隆白细胞介素1受体。
Proc Natl Acad Sci U S A. 1989 Nov;86(22):8946-50. doi: 10.1073/pnas.86.22.8946.
2
Expression cloning of the murine and human interleukin 9 receptor cDNAs.小鼠和人类白细胞介素9受体cDNA的表达克隆
Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5690-4. doi: 10.1073/pnas.89.12.5690.
3
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.白细胞介素-1受体的cDNA表达克隆，免疫球蛋白超家族成员之一。
Science. 1988 Jul 29;241(4865):585-9. doi: 10.1126/science.2969618.
4
Molecular cloning and expression of the human interleukin 5 receptor.人白细胞介素5受体的分子克隆与表达
J Exp Med. 1992 Feb 1;175(2):341-51. doi: 10.1084/jem.175.2.341.
5
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.人及小鼠白细胞介素-7受体的克隆：可溶性形式的证明及其与新受体超家族的同源性
Cell. 1990 Mar 23;60(6):941-51. doi: 10.1016/0092-8674(90)90342-c.
6
The chicken IL-1 receptor: differential evolution of the cytoplasmic and extracellular domains.鸡白细胞介素-1受体：胞质结构域和胞外结构域的差异进化
Gene. 1992 Feb 15;111(2):239-43. doi: 10.1016/0378-1119(92)90693-j.
7
Molecular cloning of cDNA encoding human interleukin-2 receptor.编码人白细胞介素-2受体的cDNA的分子克隆
Nature. 1984;311(5987):631-5. doi: 10.1038/311631a0.
8
Evidence for different interleukin 1 receptors in murine B- and T-cell lines.小鼠B细胞和T细胞系中不同白细胞介素1受体的证据。
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8034-8. doi: 10.1073/pnas.86.20.8034.
9
A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.一种通过哺乳动物表达从B细胞中克隆出的新型白细胞介素-1受体，在多种细胞类型中表达。
EMBO J. 1991 Oct;10(10):2821-32. doi: 10.1002/j.1460-2075.1991.tb07831.x.
10
Molecular cloning, characterization and functional expression of the rat liver interleukin 6 receptor.大鼠肝脏白细胞介素6受体的分子克隆、特性鉴定及功能表达
J Biol Chem. 1990 Nov 15;265(32):19853-62.
引用本文的文献
1
-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity.与未修饰的纳米抗体连接的环辛烯笼化白细胞介素-1β免疫细胞因子构建体允许基于点击-2-释放的细胞因子活性控制。
RSC Chem Biol. 2025 Jun 4. doi: 10.1039/d5cb00113g.
2
Innate Immunity in Hepatitis C Virus Infection.丙型肝炎病毒感染中的固有免疫
Cold Spring Harb Perspect Med. 2021 Feb 1;11(2):a036988. doi: 10.1101/cshperspect.a036988.
3
Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation.丙型肝炎病毒核心蛋白对钙信号通路的调节刺激 NLRP3 炎性体的激活。
PLoS Pathog. 2019 Feb 27;15(2):e1007593. doi: 10.1371/journal.ppat.1007593. eCollection 2019 Feb.
4
Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells.在外周非免疫细胞中表达的 1 型白细胞介素 1 受体。
Sci Rep. 2018 Jan 15;8(1):723. doi: 10.1038/s41598-018-19248-7.
5
NLRC4 inflammasomopathies.NLRC4炎性小体病
Curr Opin Allergy Clin Immunol. 2017 Dec;17(6):398-404. doi: 10.1097/ACI.0000000000000396.
6
Abnormal gene expression of proinflammatory cytokines and their membrane-bound receptors in the lymphocytes of depressed patients.抑郁症患者淋巴细胞中促炎细胞因子及其膜结合受体的基因表达异常。
Psychiatry Res. 2016 Jun 30;240:314-320. doi: 10.1016/j.psychres.2016.04.049. Epub 2016 Apr 22.
7
Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1.表达白细胞介素-1受体1型条件等位基因的小鼠的产生与鉴定
PLoS One. 2016 Mar 1;11(3):e0150068. doi: 10.1371/journal.pone.0150068. eCollection 2016.
8
Abnormal gene expression of proinflammatory cytokines and their receptors in the lymphocytes of patients with bipolar disorder.双相情感障碍患者淋巴细胞中促炎细胞因子及其受体的基因表达异常。
Bipolar Disord. 2015 Sep;17(6):636-44. doi: 10.1111/bdi.12320. Epub 2015 Aug 8.
9
Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis.白细胞介素-1受体2型与c-Fos共同作用，增强结肠癌细胞中白细胞介素-6和血管内皮生长因子A的表达并诱导血管生成。
J Biol Chem. 2015 Sep 4;290(36):22212-24. doi: 10.1074/jbc.M115.644823. Epub 2015 Jul 24.
10
Proinflammatory cytokines and their membrane-bound receptors are altered in the lymphocytes of schizophrenia patients.促炎细胞因子及其膜结合受体在精神分裂症患者的淋巴细胞中发生改变。
Schizophr Res. 2015 May;164(1-3):193-8. doi: 10.1016/j.schres.2015.02.004. Epub 2015 Mar 4.
本文引用的文献
1
Interleukin 1, a potential regulator of fibroblast proliferation.白细胞介素1，一种成纤维细胞增殖的潜在调节因子。
J Immunol. 1982 May;128(5):2177-82.
2
Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).部分纯化的淋巴细胞激活因子（白细胞介素1）对类风湿性滑膜细胞胶原酶和前列腺素产生的刺激作用。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2474-7. doi: 10.1073/pnas.78.4.2474.
3
Protein import into the cell nucleus.蛋白质导入细胞核。
Annu Rev Cell Biol. 1986;2:367-90. doi: 10.1146/annurev.cb.02.110186.002055.
4
Interleukin 1 induces specific phosphorylation of a 41 kDa plasma membrane protein from the human tumor cell line K 562.白细胞介素1可诱导人肿瘤细胞系K 562的一种41 kDa质膜蛋白发生特异性磷酸化。
Immunobiology. 1986 Apr;171(3):165-9. doi: 10.1016/S0171-2985(86)80001-8.
5
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.蛋白激酶家族：催化结构域的保守特征与推导的系统发育
Science. 1988 Jul 1;241(4861):42-52. doi: 10.1126/science.3291115.
6
Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins.白细胞介素1和肿瘤坏死因子可增加成纤维细胞蛋白的磷酸化。
FEBS Lett. 1988 Dec 5;241(1-2):6-10. doi: 10.1016/0014-5793(88)81019-6.
7
Interleukin 1 and the glomerular mesangium. III. IL-1-dependent stimulation of mesangial cell protein kinase activity.白细胞介素1与肾小球系膜。III. 白细胞介素1对系膜细胞蛋白激酶活性的依赖性刺激
Kidney Int. 1988 Jul;34(1):26-35. doi: 10.1038/ki.1988.141.
8
Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1.人白细胞中一种65千道尔顿胞质磷蛋白的纯化与特性分析，其磷酸化作用因白细胞介素1刺激而增强。
Biochemistry. 1988 May 17;27(10):3765-70. doi: 10.1021/bi00410a037.
9
Interleukin-1 regulation of hematopoietic growth factor production by human stromal fibroblasts.白细胞介素-1对人基质成纤维细胞造血生长因子产生的调节作用
J Cell Physiol. 1988 Feb;134(2):292-6. doi: 10.1002/jcp.1041340217.
10
Detection and characterization of high affinity plasma membrane receptors for human interleukin 1.人白细胞介素1高亲和力质膜受体的检测与特性分析
J Exp Med. 1985 Aug 1;162(2):501-15. doi: 10.1084/jem.162.2.501.
Zotero 插件