Sweeney T, O'Halloran A M, Hamill R M, Davey G C, Gil M, Southwood O I, Ryan M T
School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Teagasc, Ashtown Food Research Centre, Ashtown, Dublin 15, Ireland.
Meat Sci. 2015 Feb;100:32-40. doi: 10.1016/j.meatsci.2014.09.014. Epub 2014 Sep 28.
This study examines associations between SNPs in the promoter region of the fatty acid binding protein 3 (FABP3) gene and fatness traits in pure bred Large White (n=98), Duroc (n=99) and Pietrain (n=98) populations. In the Large White breed, SNP g.-634 C>A was associated a 27% increase in IMF (%) in the heterozygote (CA) and a 38% increase in the homozygote (CC) relative to the (AA) genotype in the M. semimembranosus (SM) muscle (P=0.02). While the associations observed in this breed were suggestive of significance in both the SM and in the M. longissimus thoracis et lumborum (LTL) (P=0.08), these associations no longer attained significance at thresholds adjusted for multiple testing. In conclusion, SNPs in the FABP3 promoter may contribute to IMF without influencing carcass fatness traits in pigs, however further confirmation of these associations in larger independent populations would be essential before their incorporation into breeding programmes.
本研究检测了脂肪酸结合蛋白3（FABP3）基因启动子区域的单核苷酸多态性（SNP）与纯种大白猪（n = 98）、杜洛克猪（n = 99）和皮特兰猪（n = 98）群体中脂肪性状之间的关联。在大白猪品种中，相对于半膜肌（SM）中（AA）基因型，单核苷酸多态性g.-634 C>A在杂合子（CA）中与肌内脂肪（IMF）（%）增加27%相关，在纯合子（CC）中增加38%（P = 0.02）。虽然在该品种中观察到的关联在半膜肌和胸腰最长肌（LTL）中均提示有显著性（P = 0.08），但在经多重检验校正的阈值下，这些关联不再具有显著性。总之，FABP3启动子中的单核苷酸多态性可能有助于猪的肌内脂肪含量，而不影响胴体脂肪性状，然而，在将这些关联纳入育种计划之前，在更大的独立群体中进一步证实这些关联至关重要。
