Kolesnikova L I, Vlasov B Ia, Kravtsova O V, Dolgikh M I, Natiaganova L V
Vestn Ross Akad Med Nauk. 2014(3-4):50-4. doi: 10.15690/vramn.v69i3-4.995.
Among the metabolic processes involved in the formation of physical and sexual development of adolescents recently the system of lipid peroxidation and antioxidant protection (LPO-AOP) supporting the redox state of organism and its adaptive response under the influence of different factors is highlighted.
The aim of this work is an analysis LPO-AOP-parameters in adolescent girls of different groups of health depending on where they live.
We examined 143 girls aged 15-17 years who had the second and the third groups of health and lived in the village and the city. For assessment of LPO-AOP parameters spectrophotometric, spectrofluorometric and statistical methods were used.
The combination of high concentration of unsaturated lipids with primary accumulation of lipid peroxidation products and the stable level of the end products of lipid peroxidation were found in girls rural both groups of health. State of the antioxidant defense system in girls of the village was characterized by a high content of its components, except for alpha-tocopherol. It concentration was reduced in girls of the third group of health. The levels of lipid peroxidation secondary intermediats were elevated and oxidized glutathione level was reduced in city girls of the third groups of health.
The usage of oxidized glutathione for the prevention of exacerbations of chronic diseases in city girls of the third group of health is recommended.
在青少年身体和性发育形成所涉及的代谢过程中，最近脂质过氧化和抗氧化保护系统（LPO - AOP）受到关注，该系统维持机体的氧化还原状态及其在不同因素影响下的适应性反应。
本研究旨在分析不同健康组别的青春期女孩中LPO - AOP参数与居住地点的关系。
我们检查了143名年龄在15 - 17岁、健康状况为第二和第三组、分别居住在农村和城市的女孩。使用分光光度法、荧光分光光度法和统计方法评估LPO - AOP参数。
在农村两组健康状况的女孩中，发现不饱和脂质高浓度与脂质过氧化产物的初步积累以及脂质过氧化终产物的稳定水平相结合。农村女孩抗氧化防御系统的状态表现为其成分含量高，但α - 生育酚除外，第三组健康状况女孩中其浓度降低。第三组健康状况城市女孩中脂质过氧化二级中间体水平升高，氧化型谷胱甘肽水平降低。
建议对第三组健康状况的城市女孩使用氧化型谷胱甘肽预防慢性病急性发作。
