Research Сenter for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Bull Exp Biol Med. 2021 Jan;170(3):308-311. doi: 10.1007/s10517-021-05057-y. Epub 2021 Jan 16.
We studied changes in LPO processes and antioxidant protection system in women with ovarian hyperandrogenism at various periods of reproductive age 18-45 years. An age-related decrease in total antioxidant activity and accumulation of secondary LPO products, ketodiens and coupled trienes, were found; these changes were accompanied by an increase in the level of superoxide dismutase and a decrease in the concentrations of reduced glutathione, α-tocopherol, and retinol. Women of early reproductive age (18-35 years) with hyperandrogenism were characterized by increased content of oxidized glutathione accompanied by a decrease in the level of α-tocopherol and retinol in comparison with the control group. In women of late reproductive age (35-45 years) with hyperandrogenism, increased superoxide dismutase activity in comparison with the control group was revealed.
我们研究了不同生殖年龄段（18-45 岁）的女性卵巢雄激素过多症患者体内 LPO 过程和抗氧化保护系统的变化。研究发现，总抗氧化活性随年龄的增长而降低，同时二级 LPO 产物酮二烯和偶联三烯的积累增加；这些变化伴随着超氧化物歧化酶水平的升高和还原型谷胱甘肽、α-生育酚和视黄醇浓度的降低。与对照组相比，早生殖期（18-35 岁）的雄激素过多症患者体内氧化型谷胱甘肽含量增加，而 α-生育酚和视黄醇的水平降低。晚生殖期（35-45 岁）的雄激素过多症患者体内超氧化物歧化酶的活性增加。
