Zetterberg Madeleine, Nyström Alf, Kalaboukhova Lada, Magnusson Gunilla
Department of Clinical Neuroscience and Rehabilitation/Ophthalmology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; The Eye Clinic at Sahlgrenska University Hospital, Mölndal, Sweden.
Acta Ophthalmol. 2015 May;93(3):269-75. doi: 10.1111/aos.12566. Epub 2014 Oct 12.
To describe a paediatric cohort surgically treated for primary or secondary glaucoma (PG/SG), with regard to incidences, visual outcome and control of intraocular pressure (IOP).
All children (n = 29, 42 eyes in total) surgically treated for PG or SG at the age of 4 years or younger between January 2002 and December 2010 at Sahlgrenska University Hospital in Mölndal were retrospectively studied through medical records. Median follow-up time after initial surgery was 5.9 years (range 2.4-11.2 years).
The incidence of primary congenital glaucoma was 4.3 cases per 100 000 live births in the county of Västra Götaland. For glaucoma secondary to cataract surgery, the incidence was 13% with a median postoperative duration to diagnosis of glaucoma of 3.8 months (range 1.6 months to 4.3 years). Preoperative mean IOP was 31.5 (SD 8.1) mmHg, and mean IOP at last visit was 17.1 (SD 4.4) mmHg. For the entire cohort, 30% of the glaucoma eyes required more than two IOP-lowering surgical procedures during the study period. BCVA was ≥0.3 (decimal) in 45% of glaucomatous eyes at last follow-up with no statistically significant difference between PG and SG. Analysis of functional visual outcome, that is BCVA in the better eye, showed that 83% of all patients attained a BCVA of ≥0.5.
The incidences and outcome of surgically treated paediatric glaucoma were in accordance with previous studies. Chamber angle surgery, and if necessary, tube implantation without the use of antimetabolites, is a favourable approach leaving most sites needed for future glaucoma surgery unaffected.
描述接受原发性或继发性青光眼(PG/SG)手术治疗的儿科队列,涉及发病率、视力结果和眼压(IOP)控制情况。
对2002年1月至2010年12月期间在莫恩达尔的萨尔格伦斯卡大学医院接受PG或SG手术治疗的所有4岁及以下儿童(n = 29,共42只眼)进行回顾性病历研究。初次手术后的中位随访时间为5.9年(范围2.4 - 11.2年)。
西约塔兰省原发性先天性青光眼的发病率为每10万活产4.3例。白内障手术后继发性青光眼的发病率为13%,青光眼诊断的术后中位持续时间为3.8个月(范围1.6个月至4.3年)。术前平均眼压为31.5(标准差8.1)mmHg,最后一次随访时的平均眼压为17.1(标准差4.4)mmHg。在整个队列中,30%的青光眼眼在研究期间需要进行超过两次降低眼压的手术程序。最后一次随访时,45%的青光眼眼最佳矫正视力(BCVA)≥0.3(小数),PG和SG之间无统计学显著差异。对功能性视力结果(即较好眼的BCVA)的分析表明,83%的所有患者BCVA≥0.5。
手术治疗的儿科青光眼的发病率和结果与先前的研究一致。房角手术,如有必要,在不使用抗代谢药物的情况下植入引流管,是一种有利的方法,不会影响未来青光眼手术所需的大多数部位。