影像学孤立综合征中的脑萎缩
Brain atrophy in radiologically isolated syndromes.
作者信息
Rojas Juan Ignacio, Patrucco Liliana, Míguez Jimena, Besada Cristina, Cristiano Edgardo
机构信息
Multiple Sclerosis Center of Buenos Aires (CEMBA), Neurology Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
出版信息
J Neuroimaging. 2015 Jan-Feb;25(1):68-71. doi: 10.1111/jon.12182. Epub 2014 Oct 13.
INTRODUCTION
The aim of this study was to compare brain atrophy in radiologically isolated syndrome (RIS), in clinically isolated syndrome (CIS), and in individuals with subjective complaints (ISC).
METHODS
Patients with RIS were included prospectively during June 2009 to June 2012. CIS patients and ISC were used to compare the RIS sample. An automated analysis tool, SIENAX, was used to obtain normalized total brain volume (NTBV), normalized cortical volume (NCV), and normalized white matter volume (NWMV). ANOVA test was used to analyze the data.
RESULTS
A total of 10 RIS patients, 43 CIS patients, and 29 ISC were included. The NTBV in RIS was 1.56 mm(3) × 10(6) , 1.52 × 10(6) in CIS, and 1.64 × 10(6) in ISC (P = .12 vs. CIS and P = .003 vs. ISC); the NCV in RIS was .59 × 10(6) , .55 × 10(6) in CIS, and .71 × 10(6) in ISC (P = .22 vs. CIS and P = .002 vs. ISC), and NWMV in RIS was 1.1 × 10(6) , 1 in CIS and 1.12 × 10(6) in ISC (P = .66 vs. CIS and P = .12 vs.
ISC) CONCLUSIONS: NTBV and NCV were significantly lower in RIS compared with ISC while no differences were observed in NWMV.
引言
本研究旨在比较放射学孤立综合征（RIS）、临床孤立综合征（CIS）以及有主观症状个体（ISC）的脑萎缩情况。
方法
前瞻性纳入2009年6月至2012年6月期间的RIS患者。将CIS患者和ISC患者用于与RIS样本进行比较。使用自动分析工具SIENAX获取标准化全脑体积（NTBV）、标准化皮质体积（NCV）和标准化白质体积（NWMV）。采用方差分析检验对数据进行分析。
结果
共纳入10例RIS患者、43例CIS患者和29例ISC患者。RIS患者的NTBV为1.56 mm(3)×10(6)，CIS患者为1.52×10(6)，ISC患者为1.64×10(6)（与CIS相比，P = 0.12；与ISC相比，P = 0.003）；RIS患者的NCV为0.59×10(6)，CIS患者为0.55×10(6)，ISC患者为0.71×10(6)（与CIS相比，P = 0.22；与ISC相比，P = 0.002），RIS患者的NWMV为1.1×10(6)，CIS患者为1，ISC患者为1.12×10(6)（与CIS相比，P = 0.66；与ISC相比，P = 0.12）。结论：与ISC相比，RIS患者的NTBV和NCV显著更低，而NWMV未观察到差异。
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