Khan Muhammad, Joseph Frank
Countess of Chester Hospital NHS Foundation Trust, Countess of Chester Health Park, Liverpool Road, Chester CH2 1UL, UK.
Scientifica (Cairo). 2014;2014:328592. doi: 10.1155/2014/328592. Epub 2014 Sep 17.
2014 marks the 20th anniversary of adipokines. Through the identification of leptin, our perceived understanding of adipose tissue was changed instantaneously. From a simple dormant site of energy storage, adipose tissue is now recognized as an integral hub of various hormones known as adipokines. Although great strides have been made in characterizing these hormones in health, research also shows they are significantly implicated in a series of pathologies. One such condition is obesity. Defined as an excess of adipose tissue, obesity remains one of the greatest healthcare epidemics of the 21st century. With no definitive treatment, attention has shifted to understanding the role of adipokines in obesity. This review provides an introduction to the salient obesity-related adipokines and their possible application as a treatment for obesity.
2014年是脂肪因子发现20周年。随着瘦素的发现，我们对脂肪组织的认知瞬间发生了改变。脂肪组织不再仅仅是一个简单的能量储存休眠场所，现在它被认为是各种被称为脂肪因子的激素的重要枢纽。尽管在健康状态下对这些激素的特性研究已经取得了很大进展，但研究也表明它们与一系列病理状况密切相关。肥胖就是其中一种情况。肥胖被定义为脂肪组织过多，它仍然是21世纪最严重的医疗流行病之一。由于没有明确的治疗方法，注意力已经转移到了解脂肪因子在肥胖中的作用。这篇综述介绍了与肥胖相关的重要脂肪因子及其作为肥胖治疗方法的可能应用。
