Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Sichuan Province, China.
Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong SAR, China.
PLoS One. 2014 Oct 13;9(10):e109776. doi: 10.1371/journal.pone.0109776. eCollection 2014.
To determine whether abdominal regional fat distribution pattern on MRI is correlated with cholecystolithiasis.
Magnetic resonance imaging (MRI) of 163 patients with cholecystolithiasis and 163 non-cholecystolithiasis control subjects admitted to our institution between March 2011 and September 2013 were included in this cross-sectional evaluation. There were 98 women and 65 men in cholecystolithiasis group with an average age of 57±16 years (range 25-86 years). There were 87 women and 76 men in the control group with an average age of 41±16 years (range 14-77 years). Visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT) and total abdominal adipose tissue (TAT) of all the subjects at navel level were measured on abdominal MRI. According to the visceral adipose area (cut-off point VAT = 100 cm2), study subjects were divided into 1) increased accumulation of intra-abdominal fat and 2) normal distribution of intra-abdominal fat. Logistic regression was used to assess the association of fat with the presence of cholecystolithiasis, adjusted for age and sex.
The incidence of increased intra-abdominal fat accumulation in the cholecystolithiasis group was significantly higher than that of the control group (P = 0.000). After adjusting for age and sex, cholecystolithiasis was associated with a one standard deviation increment in the waist circumference (WC) (OR = 1.44; 95%CI: 1.01,1.93; p = 0.00), VAT (OR = 4.26; 95%CI: 1.85,5.29; p = 0.00), VAT/SAT (OR = 8.66; 95%CI: 1.60,12.63; p = 0.00), and VAT/TAT (OR = 6.73; 95%CI: 4.24,12.18; p = 0.00), but not with fat content in the abdominal subcutaneous fat (p = 0.19).
The visceral adipose tissue and distribution proportion of abdominal adipose tissue are correlates of cholecystolithiasis.
确定磁共振成像（MRI）上腹部区域性脂肪分布模式是否与胆囊结石病有关。
本研究采用病例对照研究，纳入 2011 年 3 月至 2013 年 9 月期间我院收治的 163 例胆囊结石病患者和 163 例非胆囊结石病对照患者的 MRI 资料。胆囊结石病组患者中，男 65 例，女 98 例，平均年龄 57±16 岁（25-86 岁）；对照组中，男 76 例，女 87 例，平均年龄 41±16 岁（14-77 岁）。所有患者于脐水平行腹部 MRI 检查，测量内脏脂肪组织（VAT）、腹部皮下脂肪组织（SAT）和全腹脂肪组织（TAT）。根据内脏脂肪面积（VAT 切点值=100cm2），将研究对象分为 1）腹腔内脂肪过度堆积，2）腹腔内脂肪分布正常。采用 Logistic 回归分析评估脂肪与胆囊结石病之间的关系，并对年龄和性别进行校正。
胆囊结石病组中腹腔内脂肪过度堆积的发生率明显高于对照组（P=0.000）。在校正年龄和性别后，胆囊结石病与腰围（WC）增加一个标准差有关（OR=1.44；95%CI：1.01，1.93；p=0.00）、VAT（OR=4.26；95%CI：1.85，5.29；p=0.00）、VAT/SAT（OR=8.66；95%CI：1.60，12.63；p=0.00）和 VAT/TAT（OR=6.73；95%CI：4.24，12.18；p=0.00）有关，但与腹部皮下脂肪的脂肪含量无关（p=0.19）。
内脏脂肪组织和腹部脂肪组织的分布比例与胆囊结石病有关。
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