State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, People's Republic of China.
J Nat Prod. 2014 Oct 24;77(10):2234-40. doi: 10.1021/np500483d. Epub 2014 Oct 13.
Five new pentasaccharide resin glycosides, named merremins A-E (1-5), two new pentasaccharide resin glycoside methyl esters, named merremins F and G (6, 7), and four known resin glycosides, murucoidin IV, murucoidin V, stoloniferin IV, and murucoidin XVII, were obtained from the aerial parts of Merremia hederacea. This is the first report of resin glycosides obtained from M. hederacea. In addition, the new compounds can be divided into three types: those possessing an 18-membered ring (1-4), compound 5 with a 20-membered ring, and those with an acyclic core (6, 7). Furthermore, the different types of resin glycosides were evaluated for their multidrug resistance reversal activities. Compounds 1, 5, 6, and murucoidin V were noncytotoxic and enhanced the cytotoxicity of vinblastine by 2.3-142.5-fold at 25 μM. Compound 5 and murucoidin V, with 20-membered rings, were more active than compound 1, with an 18-membered ring.
从五爪金龙（Merremia hederacea）的地上部分中分离得到五个新的五糖树脂糖苷，分别命名为 merremin A-E（1-5），两个新的五糖树脂糖苷甲酯，命名为 merremin F 和 G（6,7），以及四个已知的树脂糖苷，即 murucoidin IV、murucoidin V、stoloniferin IV 和 murucoidin XVII。这是首次从 M. hederacea 中获得树脂糖苷的报道。此外，这些新化合物可分为三类：具有 18 元环的化合物（1-4），具有 20 元环的化合物 5，以及具有无环核心的化合物（6,7）。此外，对不同类型的树脂糖苷进行了多药耐药逆转活性评估。化合物 1、5、6 和 murucoidin V 非细胞毒性，在 25 μM 时将长春碱的细胞毒性增强了 2.3-142.5 倍。具有 20 元环的化合物 5 和 murucoidin V 比具有 18 元环的化合物 1 更具活性。
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