Ono Masateru, Shimohara Takaaki, Yuhara Nobuyoshi, Matsubara Souta, Yasuda Shin, Tsuchihashi Ryota, Okawa Masafumi, Kinjo Junei, Yoshimitsu Hitoshi, Nohara Toshihiro
School of Agriculture, Tokai University, Higashi-ku, Kumamoto, Japan.
Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan-ku, Fukuoka, Japan.
Nat Prod Res. 2023 Apr;37(8):1328-1337. doi: 10.1080/14786419.2021.2005593. Epub 2021 Nov 24.
Four new resin glycosides with macrolactone structures (jalapins), namely, calyhedins VII ()-X (), were isolated from the rhizomes of Wall. (Convolvulaceae). The structures of - were determined based on spectroscopic data. They were classified into three ring types: a 27-membered ring (), a 22-membered ring (, ), and a 23-membered ring (). Their sugar moieties were partially acylated using five organic acids, including ()-2-methylbut-2-enoic acid, 2-methylbutyric acid, and 2 -methyl-3-hydroxybutyric acid. Compound was the first genuine resin glycoside with calyhedic acid F as the glycosidic acid component. Additionally, the cytotoxic activities of , , and towards HL-60 human promyelocytic leukaemia cells were evaluated. All compounds demonstrated almost the same activity as the positive control, cisplatin.
从旋花科植物的根茎中分离出四种具有大环内酯结构的新树脂糖苷（泻根素），即卡里赫丁VII（）-X（）。基于光谱数据确定了-的结构。它们被分为三种环类型：一个27元环（）、一个22元环（，）和一个23元环（）。它们的糖部分用五种有机酸进行了部分酰化，包括（）-2-甲基丁-2-烯酸、2-甲基丁酸和2-甲基-3-羟基丁酸。化合物是第一种以卡里赫酸F作为糖苷酸成分的真正树脂糖苷。此外，评估了、和对HL-60人早幼粒细胞白血病细胞的细胞毒性活性。所有化合物表现出与阳性对照顺铂几乎相同的活性。
