青霉素和壮观霉素用于治疗由淋病奈瑟菌引起的尿道炎和宫颈炎的效果：耐青霉素菌株的高流行率。
Effect of penicillin and spectinomycin given for urethritis and cervicitis with Neisseria gonorrhoeae: high prevalence of penicillin-resistant isolates.
作者信息
Kouri Y H, González L, Pérez M, Menar R, Gadea C R, Kraiselburd E, Torres-Bauza L J
机构信息
Health Department of the Commonwealth of Puerto Rico.
出版信息
Genitourin Med. 1989 Oct;65(5):342-6. doi: 10.1136/sti.65.5.342.
Efficacy of single-dose spectinomycin (TRO: 2 g intramuscularly) was compared with that of aqueous procaine penicillin G (APPG:4.8 x 10(6) units) plus 1 g of probenecid for treatment of gonococcal urethritis and cervicitis. Cure rates of the 210 patients who received TRO and 190 patients who received APPG were 97.6% and 91.1%, respectively. MICs of antibiotics were determined using the agar dilution method. Those isolates with MICs of APPG of less than 1.0 microgram/ml had low failure rates (2.9%), while strains with increased resistance to APPG (MICs greater than or equal to 1.0 microgram/ml) had higher failure rates (24%). Treatment failures seen with TRO were not correlated to isolates with the higher MICs. Clinical results suggest TRO could be given for treatment of genital gonorrhoea in Puerto Rico due to the high prevalence of both chromosomally-mediated penicillin-resistant Neisseria gonorrhoeae (20%) and penicillinase-producing Neisseria gonorrhoeae (7.5%) strains and the high rate of failure seen with the use of APPG.
将单剂量大观霉素（TRO：2g肌内注射）与普鲁卡因青霉素G水剂（APPG：4.8×10⁶单位）加1g丙磺舒治疗淋菌性尿道炎和宫颈炎的疗效进行了比较。接受TRO治疗的210例患者和接受APPG治疗的190例患者的治愈率分别为97.6%和91.1%。采用琼脂稀释法测定抗生素的最低抑菌浓度（MIC）。APPG的MIC小于1.0微克/毫升的分离株失败率较低（2.9%），而对APPG耐药性增加（MIC大于或等于1.0微克/毫升）的菌株失败率较高（24%）。TRO治疗失败与MIC较高的分离株无关。临床结果表明，由于染色体介导的青霉素耐药淋病奈瑟菌（20%）和产青霉素酶淋病奈瑟菌（7.5%）菌株的高流行率以及使用APPG时较高的失败率，在波多黎各可使用TRO治疗生殖器淋病。
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