Boegehold M A, Kotchen T A
Department of Medicine, West Virginia University School of Medicine, Morgantown, 26506.
Hypertension. 1989 Dec;14(6):579-83. doi: 10.1161/01.hyp.14.6.579.
The effect of dietary NaCl on blood pressure has generally been attributed to the sodium ion. However, recent evidence indicates that the anion accompanying sodium plays an important role in determining the magnitude of the blood pressure increase in response to a high dietary intake of NaCl. The purpose of this review is to describe studies of blood pressure responses in several experimental models of salt-sensitive hypertension and in hypertensive humans to selective dietary sodium loading (without chloride) and to selective dietary chloride loading (without sodium). The full expression of salt sensitivity depends on high dietary intakes of both sodium and chloride. This observation has implications for understanding mechanisms contributing to NaCl-induced hypertension in the susceptible host.
膳食氯化钠对血压的影响一般归因于钠离子。然而，最近的证据表明，与钠相伴的阴离子在决定因高膳食氯化钠摄入量而导致的血压升高幅度方面起着重要作用。本综述的目的是描述在几种盐敏感性高血压实验模型以及高血压患者中，对选择性膳食钠负荷（无氯）和选择性膳食氯负荷（无钠）的血压反应研究。盐敏感性的充分表现取决于高膳食钠和氯摄入量。这一观察结果对于理解易感宿主中氯化钠诱导高血压的机制具有启示意义。
