Motoyama T, Sano H, Suzuki H, Kawaguchi K, Fukuzaki H, Yamanishi J, Furuta Y, Omatsu T, Saito K
First Department of Internal Medicine, Kobe University School of Medicine, Japan.
Jpn Circ J. 1987 Oct;51(10):1191-8. doi: 10.1253/jcj.51.1191.
Selective sodium loading attenuated the development of hypertension in the deoxycorticosterone acetate (DOCA) treated rat. The DOCA treated rat fed a diet equimolar in sodium to a 7% sodium chloride diet and in chloride to a standard diet, differed in various parameters from the DOCA treated rat fed a 7% sodium chloride diet: it had higher sodium concentration in both erythrocytes and muscles, a higher erythrocyte ouabain sensitive 22Na efflux rate constant (Kos), and a lower norepinephrine turnover rate in the heart and the spleen. These results suggest that the suppressed sympathetic nervous system activity and the activated cell membrane sodium pump contribute in part to the mechanism for the suppression of the development of hypertension in the DOCA-selective sodium loaded rat.
选择性钠负荷减轻了醋酸脱氧皮质酮（DOCA）处理大鼠的高血压发展。用与7%氯化钠饮食钠等摩尔且与标准饮食氯等摩尔的饮食喂养的DOCA处理大鼠，在各种参数上与用7%氯化钠饮食喂养的DOCA处理大鼠不同：其红细胞和肌肉中的钠浓度更高，红细胞哇巴因敏感的22Na外流速率常数（Kos）更高，心脏和脾脏中的去甲肾上腺素周转率更低。这些结果表明，交感神经系统活性的抑制和细胞膜钠泵的激活部分促成了DOCA选择性钠负荷大鼠高血压发展受抑制的机制。
