1] Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany [2] German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany.
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Mol Psychiatry. 2015 May;20(5):585-93. doi: 10.1038/mp.2014.114. Epub 2014 Oct 14.
Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical region for recall and recognition memory. In a mechanistic proof-of-concept intervention over 3 months, we investigated whether healthy older adults (60-77 years) also show such plasticity. Regional cerebral blood flow (rCBF) and volume (rCBV) were measured with gadolinium-based perfusion imaging (3 Tesla magnetic resonance image (MRI)). Hippocampal volumes were assessed by high-resolution 7 Tesla MRI. Fitness improvement correlated with changes in hippocampal perfusion and hippocampal head volume. Perfusion tended to increase in younger, but to decrease in older individuals. The changes in fitness, hippocampal perfusion and volume were positively related to changes in recognition memory and early recall for complex spatial objects. Path analyses indicated that fitness-related changes in complex object recognition were modulated by hippocampal perfusion. These findings indicate a preserved capacity of the aging human hippocampus for functionally relevant vascular plasticity, which decreases with progressing age.
有氧运动可诱导年轻人海马体的血管可塑性，而海马体是回忆和识别记忆的关键区域。在一项为期 3 个月的机制验证性干预研究中，我们研究了健康的老年人（60-77 岁）是否也具有这种可塑性。通过基于钆的灌注成像（3 特斯拉磁共振成像（MRI））测量局部脑血流（rCBF）和体积（rCBV）。通过高分辨率 7 特斯拉 MRI 评估海马体体积。体能改善与海马灌注和海马头部体积的变化相关。灌注在年轻人中趋于增加，而在老年人中趋于减少。体能、海马灌注和体积的变化与复杂空间物体的识别记忆和早期回忆的变化呈正相关。路径分析表明，与海马灌注相关的复杂物体识别的体能变化受到调节。这些发现表明，衰老的人类海马体具有与功能相关的血管可塑性的能力，随着年龄的增长而降低。
