Lee M M, Rajagopalan L, Berg G J, Moshang T
Division of Endocrinology/Diabetes and Neonatology Children's Hospital, Philadelphia, Pennsylvania 19104.
J Clin Endocrinol Metab. 1989 Dec;69(6):1133-6. doi: 10.1210/jcem-69-6-1133.
To evaluate serum adrenal steroid concentrations in preterm infants, 17-hydroxyprogesterone (17-OHP), 17-hydroxypregnenolone, 11-deoxycortisol, cortisol, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione, 18-hydroxycorticosterone, and aldosterone values were determined in 9 sick and 13 healthy premature infants. Serum steroid concentrations were compared to previously reported data from healthy full-term infants. 17-OHP, 11-deoxycortisol, and aldosterone values were higher in sick preterm infants than in healthy preterm infants. Compared to healthy full-term infants, the premature infants-had significantly higher 17-hydroxypregnenolone, 17-OHP, and DHEA sulfate concentrations. Cortisol values were not different between the sick and healthy preterm infants and were similar to full-term values. Aldosterone values were also similar between the premature and the full-term infants. The findings of elevated steroid precursors in preterm infants and low cortisol levels in stressed sick preterm infants may indicate a relative immaturity of adrenal enzyme activity and inadequate adrenal reserve for stress.
为评估早产儿的血清肾上腺类固醇浓度，测定了9例患病早产儿和13例健康早产儿的17-羟孕酮（17-OHP）、17-羟孕烯醇酮、11-脱氧皮质醇、皮质醇、脱氢表雄酮（DHEA）、硫酸脱氢表雄酮、雄烯二酮、18-羟皮质酮和醛固酮值。将血清类固醇浓度与先前报道的健康足月儿数据进行比较。患病早产儿的17-OHP、11-脱氧皮质醇和醛固酮值高于健康早产儿。与健康足月儿相比，早产儿的17-羟孕烯醇酮、17-OHP和硫酸脱氢表雄酮浓度显著更高。患病和健康早产儿的皮质醇值无差异，且与足月儿的值相似。早产儿和足月儿的醛固酮值也相似。早产儿类固醇前体升高以及应激状态下患病早产儿皮质醇水平降低的结果可能表明肾上腺酶活性相对不成熟以及肾上腺对应激的储备不足。
