Oppeneer Sarah J, Robien Kim
1Office of Minority Health and Health Disparities,Lombardi Comprehensive Cancer Center,Georgetown University,1000 New Jersey Avenue SE,Washington,DC 20003,USA.
2Department of Epidemiology and Biostatistics,Milken Institute School of Public Health,George Washington University,Washington,DC,USA.
Public Health Nutr. 2015 Jul;18(10):1847-63. doi: 10.1017/S1368980014002213. Epub 2014 Oct 14.
To review the literature on bisphenol A (BPA) exposure and obesity in human populations.
Systematic review of the literature via searches of PubMed, EMBASE, Web of Science and reference lists for articles published to 1 August 2014.
China, Italy, Japan, Republic of Korea, Sweden, UK, USA.
Adults (≥ 18 years).
Eighteen articles were identified and included in the review. Twelve studies included secondary evaluations of BPA exposure and BMI, and six studies evaluated body composition as the primary outcome. All analyses were cross-sectional and no study included in the review received a positive quality rating (twelve negative, six neutral). Eight studies observed a statistically significant positive association between urinary or serum BPA levels and BMI, and ten studies observed no association. Studies where BMI was a primary outcome and studies of neutral quality were more likely to observe an association.
Study results are conflicting and significant methodological issues limit the ability to draw conclusions from these studies. Prospective studies that measure BPA exposure and changes in body weight and composition are needed to establish temporality, causality and the direction of any observed associations.
回顾关于人群中双酚A（BPA）暴露与肥胖的文献。
通过检索PubMed、EMBASE、科学网以及截至2014年8月1日发表文章的参考文献列表，对文献进行系统回顾。
中国、意大利、日本、韩国、瑞典、英国、美国。
成年人（≥18岁）。
共识别出18篇文章并纳入本综述。12项研究对BPA暴露和体重指数（BMI）进行了二次评估，6项研究将身体成分作为主要结局进行评估。所有分析均为横断面研究，纳入综述的研究均未获得阳性质量评级（12项为阴性，6项为中性）。8项研究观察到尿或血清BPA水平与BMI之间存在统计学显著正相关，10项研究未观察到相关性。以BMI作为主要结局的研究以及质量为中性的研究更有可能观察到相关性。
研究结果相互矛盾，重大方法学问题限制了从这些研究得出结论的能力。需要进行前瞻性研究来测量BPA暴露以及体重和身体成分的变化，以确定时间顺序、因果关系以及任何观察到的关联的方向。
