Briseño-Hernández Andrés Alejandro, Quezada-López Deissy Roxana, Castañeda-Chávez Agar, Dassaejv Macías-Amezcua Michel, Pintor-Belmontes Julio Cesar
Departamento de Patología, Hospital General de Occidente, Zapopan, Jalisco, Mexico.
Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco. Mexico.
Cir Cir. 2014 Mar-Apr;82(2):212-8.
Burkitt lymphoma, is described as an aggressive form of non-Hodgkin lymphoma of B cells which occurs most often in children and young adults, ovarian lymphoma can appear as a primary lesion or more commonly referred to as a metastasis. Primary ovarian lesions are rare manifestations corresponding to 0.5% of non-Hodgkin lymphoma and 1.5% of ovarian tumors. Clinic case: 31 years old female with general weakness, march incapacity, dyspnea, hyporexia, fever, diaphoresis, weight loss of 20 kg, flat abs with abdominal pain; Ca125 610 U/ml. Abdominal computed tomography shows a solid aspect tumor which affects the right pelvic cavity. Bilateral ovarian tumors were removed. Microscopically, both lesions show a "starry sky" pattern composed by a monotonous infiltration of lymphocytes mixed with large and clear macrophages, several atypical mitoses, and necrosis and hemorrhage areas. Immunohistochemistry was positive for CD10, CD20, and negative for CD3 and high Ki67 proliferation index. Bilateral ovarian Burkitt's lymphoma was diagnosed.
Bilateral ovarian Burkitt's lymphoma is a rare entity, with a variability of presentations, the abdominal pain and abdominal tumors are the most frequent. The patient's prognosis at short term is poor, therefore it's necessary to know this entity and make an early diagnosis.
伯基特淋巴瘤被描述为一种侵袭性B细胞非霍奇金淋巴瘤,最常发生于儿童和年轻成人,卵巢淋巴瘤可表现为原发性病变,或更常见地称为转移瘤。原发性卵巢病变是罕见表现,占非霍奇金淋巴瘤的0.5%和卵巢肿瘤的1.5%。临床病例:一名31岁女性,有全身乏力、行走无力、呼吸困难、食欲减退、发热、多汗、体重减轻20kg、腹部平坦伴腹痛;癌抗原125(Ca125)为610U/ml。腹部计算机断层扫描显示一个实性肿瘤,累及右盆腔。双侧卵巢肿瘤被切除。显微镜下,两个病变均显示“星空”模式,由淋巴细胞的单一浸润与大而清晰的巨噬细胞、多个非典型有丝分裂以及坏死和出血区域混合组成。免疫组织化学检查显示CD10、CD20呈阳性,CD3呈阴性,Ki67增殖指数高。诊断为双侧卵巢伯基特淋巴瘤。
双侧卵巢伯基特淋巴瘤是一种罕见疾病,表现多样,腹痛和腹部肿瘤最为常见。患者短期预后较差,因此有必要了解这种疾病并尽早诊断。