Stepniak Anna, Czuczwar Piotr, Szkodziak Piotr, Wozniakowska Ewa, Wozniak Slawomir, Paszkowski Tomasz
3rd Department of Gynecology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954, Lublin, Poland.
Arch Gynecol Obstet. 2017 Oct;296(4):653-660. doi: 10.1007/s00404-017-4478-6. Epub 2017 Aug 2.
This review presents the information about epidemiology, clinical manifestation, diagnosis and treatment of primary ovarian Burkitt's lymphoma (BL), including a literature search of available BL cases. The purpose of this review is to draw clinicians' attention to the possibility of ovarian BL occurrence, which may be important in the differential diagnosis of ovarian tumours.
PubMed and Web of Science databases were searched using the keywords ''Burkitt's'', ''Lymphoma'', ''Ovarian'', ''Primary'', ''Burkitt's lymphoma''. Only cases with histopathologically confirmed diagnosis of primary ovarian BL were included in this review.
Fifty articles, reporting cases with an ovarian manifestation of primary non-Hodgkin's lymphoma, were found. Twenty-one cases with a histopathologically confirmed BL were evaluated to compare various manifestations, treatment and prognosis in ovarian BL.
Primary ovarian BL is a rare condition, included in the entity of non-Hodgkin lymphoma. The tumour can occur uni- or bilaterally in the ovaries with major symptoms such as abdominal pain or a large abdominal mass. Differential diagnosis, based on imaging features and pathological examination of the specimens, is essential for further treatment due to various aetiology of ovarian tumours. Although most of the patients suffering from ovarian BL underwent surgery after the ovarian tumour had been detected, surgical treatment is not the treatment of choice in patients with ovarian lymphoma. The mainstay of therapy is chemotherapy without further surgery. The prognosis is better if the chemotherapy protocol is more aggressive and followed by prophylactic central nervous system chemotherapy. Nowadays, multiagent protocols are administered, which improves the survival rate.
本综述介绍了原发性卵巢伯基特淋巴瘤（BL）的流行病学、临床表现、诊断和治疗信息，包括对现有BL病例的文献检索。本综述的目的是引起临床医生对卵巢BL发生可能性的关注，这在卵巢肿瘤的鉴别诊断中可能很重要。
使用关键词“伯基特氏”、“淋巴瘤”、“卵巢”、“原发性”、“伯基特淋巴瘤”在PubMed和Web of Science数据库中进行检索。本综述仅纳入组织病理学确诊为原发性卵巢BL的病例。
发现50篇报告原发性非霍奇金淋巴瘤卵巢表现病例的文章。对21例组织病理学确诊为BL的病例进行评估，以比较卵巢BL的各种表现、治疗和预后。
原发性卵巢BL是一种罕见疾病，属于非霍奇金淋巴瘤范畴。肿瘤可单侧或双侧发生于卵巢，主要症状为腹痛或腹部肿块。由于卵巢肿瘤病因多样，基于影像学特征和标本病理检查的鉴别诊断对进一步治疗至关重要。虽然大多数卵巢BL患者在发现卵巢肿瘤后接受了手术，但手术治疗并非卵巢淋巴瘤患者的首选治疗方法。治疗的主要手段是化疗，无需进一步手术。如果化疗方案更积极并随后进行预防性中枢神经系统化疗，预后会更好。如今采用多药方案，提高了生存率。
