经颅直流电刺激对谷氨酸能神经传递和大规模网络连通性的基线效应。
Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity.
作者信息
Hunter Michael A, Coffman Brian A, Gasparovic Charles, Calhoun Vince D, Trumbo Michael C, Clark Vincent P
机构信息
Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA; Department of Psychology, The University of New Mexico, NM, USA; The Mind Research Network, Albuquerque, NM, USA; Department of Psychiatry, The University of New Mexico School of Medicine, Albuquerque, NM, USA.
Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA; Department of Psychology, The University of New Mexico, NM, USA; The Mind Research Network, Albuquerque, NM, USA.
出版信息
Brain Res. 2015 Jan 12;1594:92-107. doi: 10.1016/j.brainres.2014.09.066. Epub 2014 Oct 12.
Transcranial direct current stimulation (tDCS) modulates glutamatergic neurotransmission and can be utilized as a novel treatment intervention for a multitude of populations. However, the exact mechanism by which tDCS modulates the brain׳s neural architecture, from the micro to macro scales, have yet to be investigated. Using a within-subjects design, resting-state functional magnetic resonance imaging (rs-fMRI) and proton magnetic resonance spectroscopy ((1)H MRS) were performed immediately before and after the administration of anodal tDCS over right parietal cortex. Group independent component analysis (ICA) was used to decompose fMRI scans into 75 brain networks, from which 12 resting-state networks were identified that had significant voxel-wise functional connectivity to anatomical regions of interest. (1)H MRS was used to obtain estimates of combined glutamate and glutamine (Glx) concentrations from bilateral intraparietal sulcus. Paired sample t-tests showed significantly increased Glx under the anodal electrode, but not in homologous regions of the contralateral hemisphere. Increases of within-network connectivity were observed within the superior parietal, inferior parietal, left frontal-parietal, salience and cerebellar intrinsic networks, and decreases in connectivity were observed in the anterior cingulate and the basal ganglia (p<0.05, FDR-corrected). Individual differences in Glx concentrations predicted network connectivity in most of these networks. The observed relationships between glutamatergic neurotransmission and network connectivity may be used to guide future tDCS protocols that aim to target and alter neuroplastic mechanisms in healthy individuals as well as those with psychiatric and neurologic disorders.
经颅直流电刺激（tDCS）可调节谷氨酸能神经传递，并可作为针对多种人群的新型治疗干预手段。然而，tDCS从微观到宏观尺度调节大脑神经结构的确切机制尚未得到研究。采用受试者内设计，在右侧顶叶皮层施加阳极tDCS之前和之后立即进行静息态功能磁共振成像（rs-fMRI）和质子磁共振波谱（（1）H MRS）检查。使用组独立成分分析（ICA）将功能磁共振成像扫描分解为75个脑网络，从中识别出12个静息态网络，这些网络与感兴趣的解剖区域具有显著的体素级功能连接。（1）H MRS用于获取双侧顶内沟中谷氨酸和谷氨酰胺（Glx）组合浓度的估计值。配对样本t检验显示，阳极电极下的Glx显著增加，但对侧半球的同源区域未增加。在顶上叶、顶下叶、左额顶叶、突显和小脑固有网络中观察到网络内连接性增加，而在前扣带回和基底神经节中观察到连接性降低（p<0.05，经FDR校正）。Glx浓度的个体差异预测了这些网络中大多数的网络连接性。观察到的谷氨酸能神经传递与网络连接性之间的关系可用于指导未来的tDCS方案，这些方案旨在针对并改变健康个体以及患有精神和神经疾病的个体的神经可塑性机制。
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