Makker Annu, Goel Madhu Mati, Mahdi Abbas Ali
Post-Graduate Department of PathologyDepartment of BiochemistryKing George's Medical University, Lucknow 226003, Uttar Pradesh, India
Post-Graduate Department of PathologyDepartment of BiochemistryKing George's Medical University, Lucknow 226003, Uttar Pradesh, India.
J Mol Endocrinol. 2014 Dec;53(3):R103-18. doi: 10.1530/JME-14-0220. Epub 2014 Oct 13.
Abnormalities in ovarian function, including defective oogenesis and folliculogenesis, represent a key female reproductive deficiency. Accumulating evidence in the literature has shown that the PI3K/PTEN/Akt and TSC/mTOR signaling pathways are critical regulators of ovarian function including quiescence, activation, and survival of primordial follicles, granulosa cell proliferation and differentiation, and meiotic maturation of oocytes. Dysregulation of these signaling pathways may contribute to infertility caused by impaired follicular development, intrafollicular oocyte development, and ovulation. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/Akt and TSC/mTOR pathways during mammalian oogenesis and folliculogenesis and their association with female infertility.
卵巢功能异常，包括卵子发生和卵泡发生缺陷，是女性生殖功能的关键缺陷。文献中越来越多的证据表明，PI3K/PTEN/Akt和TSC/mTOR信号通路是卵巢功能的关键调节因子，包括原始卵泡的静止、激活和存活、颗粒细胞增殖和分化以及卵母细胞减数分裂成熟。这些信号通路的失调可能导致卵泡发育受损、卵泡内卵母细胞发育和排卵障碍引起的不孕。本文综述了PI3K/PTEN/Akt和TSC/mTOR通路在哺乳动物卵子发生和卵泡发生过程中的功能作用及其与女性不孕的关系的当前知识状态。
