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Response to "Human cytomegalovirus infection in tumor cells of the nervous system is not detectable with standardized pathologico-virological diagnostics".对“标准化病理病毒学诊断无法检测到神经系统肿瘤细胞中的人巨细胞病毒感染”的回应
Neuro Oncol. 2014 Nov;16(11):1435-6. doi: 10.1093/neuonc/nou295. Epub 2014 Oct 13.
2
Human cytomegalovirus infection in tumor cells of the nervous system is not detectable with standardized pathologico-virological diagnostics.采用标准化的病理病毒学诊断方法无法检测出神经系统肿瘤细胞中的人巨细胞病毒感染。
Neuro Oncol. 2014 Nov;16(11):1469-77. doi: 10.1093/neuonc/nou167. Epub 2014 Aug 25.
3
Towards an unbiased, collaborative effort to reach evidence about the presence of human cytomegalovirus in glioblastoma (and other tumors).开展一项公正、协作的工作,以获取有关胶质母细胞瘤(及其他肿瘤)中人类巨细胞病毒存在情况的证据。
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Reply to: Towards an unbiased, collaborative effort to reach evidence about the presence of human cytomegalovirus in glioblastoma (and other tumors).回复:关于为获取胶质母细胞瘤(及其他肿瘤)中人类巨细胞病毒存在情况的证据而进行公正、协作努力的探讨。
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CMV and glioma--are we there yet?巨细胞病毒与胶质瘤——我们做到了吗?
Neuro Oncol. 2014 Nov;16(11):1433-4. doi: 10.1093/neuonc/nou296.
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Cytomegalovirus and glioblastoma: a review of evidence for their association and indications for testing and treatment.巨细胞病毒与胶质母细胞瘤:关于它们之间关联的证据以及检测与治疗指征的综述
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Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival.人类巨细胞病毒感染水平在多形性胶质母细胞瘤中对生存预后具有价值。
J Clin Virol. 2013 May;57(1):36-42. doi: 10.1016/j.jcv.2012.12.018. Epub 2013 Feb 4.
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[Cytomegalovirus infection in adults: virological aspects].[成人巨细胞病毒感染:病毒学方面]
Ned Tijdschr Geneeskd. 1970 Dec 26;114(52):2199-200.
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Behavioral symptoms with intracranial neoplasm.颅内肿瘤的行为症状
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VIGAS and beyond: the impact of HCMV-infection and its treatment in glioblastoma.VIGAS及其他方面:人巨细胞病毒感染及其治疗对胶质母细胞瘤的影响
Neurosurgery. 2014 Feb;74(2):N23-4. doi: 10.1227/01.neu.0000442982.91829.da.

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Cytomegalovirus-induced oncomodulation drives immune escape in glioblastoma.巨细胞病毒诱导的肿瘤调节促进胶质母细胞瘤的免疫逃逸。
Sci Rep. 2025 Jul 17;15(1):25981. doi: 10.1038/s41598-025-10107-w.
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Presence of the Human Cytomegalovirus in Glioblastomas-A Systematic Review.胶质母细胞瘤中人类巨细胞病毒的存在——一项系统综述
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The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties.人巨细胞病毒编码的 G 蛋白偶联受体 UL33 具有致癌调节特性。
J Biol Chem. 2019 Nov 1;294(44):16297-16308. doi: 10.1074/jbc.RA119.007796. Epub 2019 Sep 13.
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Multimodal techniques failed to detect cytomegalovirus in human glioblastoma samples.多模态技术未能在人胶质母细胞瘤样本中检测到巨细胞病毒。
J Neurovirol. 2019 Feb;25(1):50-56. doi: 10.1007/s13365-018-0683-8. Epub 2018 Nov 5.
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The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth.病毒编码趋化因子受体 US28 的组成活性加速了神经胶质瘤的生长。
Oncogene. 2018 Jul;37(30):4110-4121. doi: 10.1038/s41388-018-0255-7. Epub 2018 Apr 30.
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The Immunomodulatory Capacity of an Epstein-Barr Virus Abortive Lytic Cycle: Potential Contribution to Viral Tumorigenesis.爱泼斯坦-巴尔病毒流产裂解周期的免疫调节能力:对病毒致瘤的潜在贡献
Cancers (Basel). 2018 Mar 30;10(4):98. doi: 10.3390/cancers10040098.
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Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and Hybridization.通过实时聚合酶链反应、免疫组织化学和杂交检测胶质母细胞瘤及其他高级别胶质瘤中巨细胞病毒的缺失情况
Clin Cancer Res. 2017 Jun 15;23(12):3150-3157. doi: 10.1158/1078-0432.CCR-16-1490. Epub 2016 Dec 29.
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No evidence for human cytomegalovirus infection in pediatric medulloblastomas.在儿童髓母细胞瘤中没有人类巨细胞病毒感染的证据。
Neuro Oncol. 2016 Oct;18(10):1461-2. doi: 10.1093/neuonc/now151. Epub 2016 Aug 12.
9
Towards an unbiased, collaborative effort to reach evidence about the presence of human cytomegalovirus in glioblastoma (and other tumors).开展一项公正、协作的工作,以获取有关胶质母细胞瘤(及其他肿瘤)中人类巨细胞病毒存在情况的证据。
Neuro Oncol. 2015 Jul;17(7):1039. doi: 10.1093/neuonc/nov048.
10
Cytomegalovirus and glioblastoma; controversies and opportunities.巨细胞病毒与胶质母细胞瘤:争议与机遇
J Neurooncol. 2015 Jul;123(3):465-71. doi: 10.1007/s11060-015-1734-0. Epub 2015 Feb 15.

本文引用的文献

1
Human cytomegalovirus and primary intracranial tumours: frequency of tumour infection and lack of correlation with systemic immune anti-viral responses.人巨细胞病毒与原发性颅内肿瘤:肿瘤感染的频率与全身免疫抗病毒反应缺乏相关性。
Neuropathol Appl Neurobiol. 2015 Feb;41(2):e29-40. doi: 10.1111/nan.12172.
2
Autologous T-cell therapy for cytomegalovirus as a consolidative treatment for recurrent glioblastoma.自体 T 细胞疗法治疗巨细胞病毒作为复发性胶质母细胞瘤的巩固治疗。
Cancer Res. 2014 Jul 1;74(13):3466-76. doi: 10.1158/0008-5472.CAN-14-0296. Epub 2014 May 4.
3
HCMV glycoprotein B is expressed in primary glioblastomas and enhances growth and invasiveness via PDGFR-alpha activation.人巨细胞病毒糖蛋白B在原发性胶质母细胞瘤中表达,并通过激活血小板衍生生长因子受体α增强肿瘤生长和侵袭能力。
Oncotarget. 2014 Feb 28;5(4):1091-100. doi: 10.18632/oncotarget.1787.
4
Methods for the detection of cytomegalovirus in glioblastoma cells and tissues.检测胶质母细胞瘤细胞和组织中巨细胞病毒的方法。
Methods Mol Biol. 2014;1119:165-96. doi: 10.1007/978-1-62703-788-4_11.
5
Cytomegalovirus pp71 protein is expressed in human glioblastoma and promotes pro-angiogenic signaling by activation of stem cell factor.巨细胞病毒 pp71 蛋白在人胶质母细胞瘤中表达,并通过激活干细胞因子促进促血管生成信号。
PLoS One. 2013 Jul 5;8(7):e68176. doi: 10.1371/journal.pone.0068176. Print 2013.
6
Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival.人类巨细胞病毒感染水平在多形性胶质母细胞瘤中对生存预后具有价值。
J Clin Virol. 2013 May;57(1):36-42. doi: 10.1016/j.jcv.2012.12.018. Epub 2013 Feb 4.
7
Genetic analysis of cytomegalovirus in malignant gliomas.巨细胞病毒在恶性胶质瘤中的遗传分析。
J Virol. 2012 Jun;86(12):6815-24. doi: 10.1128/JVI.00015-12. Epub 2012 Apr 11.
8
Significant association of multiple human cytomegalovirus genomic Loci with glioblastoma multiforme samples.多个人类巨细胞病毒基因组座与多形性胶质母细胞瘤样本存在显著关联。
J Virol. 2012 Jan;86(2):854-64. doi: 10.1128/JVI.06097-11. Epub 2011 Nov 16.
9
Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype.人巨细胞病毒 US28 在胶质母细胞瘤中被发现,可促进侵袭性和血管生成表型。
Cancer Res. 2011 Nov 1;71(21):6643-53. doi: 10.1158/0008-5472.CAN-11-0744. Epub 2011 Sep 7.
10
Human cytomegalovirus infection causes premature and abnormal differentiation of human neural progenitor cells.人巨细胞病毒感染导致人神经祖细胞过早和异常分化。
J Virol. 2010 Apr;84(7):3528-41. doi: 10.1128/JVI.02161-09. Epub 2010 Jan 13.

Response to "Human cytomegalovirus infection in tumor cells of the nervous system is not detectable with standardized pathologico-virological diagnostics".

作者信息

Cobbs Charles

机构信息

Swedish Neuroscience Institute, Ivy Center for Advanced Brain Tumor Treatment, Seattle, Washington.

出版信息

Neuro Oncol. 2014 Nov;16(11):1435-6. doi: 10.1093/neuonc/nou295. Epub 2014 Oct 13.

DOI:10.1093/neuonc/nou295
PMID:25313192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4201079/
Abstract
摘要