Kim Dong-Yeon, Kim Hyeon Sik, Jang Hwa Youn, Kim Ju Han, Bom Hee-Seung, Min Jung-Joon
Department of Nuclear Medicine, Chonnam National University Hwasun Hospital , Hwasun, Korea.
Department of Cardiology, Chonnam National University Medical School , Gwangju, Korea.
ACS Med Chem Lett. 2014 Sep 10;5(10):1124-8. doi: 10.1021/ml500251z. eCollection 2014 Oct 9.
The short half-life of current positron emission tomography (PET) cardiac tracers limits their widespread clinical use. We previously developed a (18)F-labeled phosphonium cation, [(18)F]FPTP, that demonstrated sharply defined myocardial defects in a corresponding infarcted myocardium. The aim of this study was to compare the image properties of PET scans obtained using [(18)F]FPTP with those obtained using [(13)N]NH3 in rat myocardial infarction models. Perfusion abnormality was analyzed in 17 segments of polar map images. The myocardium-to-liver and myocardium-to-lung ratios of [(18)F]FPTP were 10.48 and 2.65 times higher, respectively, than those of [(13)N]NH3 in images acquired 30 min after tracer injection. The myocardial defect size measured by [(18)F]FPTP correlated more closely with the hypoperfused area measured by quantitative 2,3,5-triphenyltetrazolium chloride staining (r = 0.89, P < 0.01) than did [(13)N]NH3 (r = 0.84, P < 0.01). [(18)F]FPTP might be useful as a replacement for the myocardial agent [(13)N]NH3 in cardiac PET/CT applications.
目前正电子发射断层扫描（PET）心脏示踪剂的半衰期较短，限制了它们在临床上的广泛应用。我们之前研发了一种（18）F标记的鏻阳离子[（18）F]FPTP，它在相应梗死心肌中显示出清晰明确的心肌缺损。本研究的目的是在大鼠心肌梗死模型中比较使用[（18）F]FPTP获得的PET扫描图像特性与使用[（13）N]NH3获得的图像特性。在极坐标图图像的17个节段中分析灌注异常情况。在示踪剂注射后30分钟采集的图像中，[（18）F]FPTP的心肌与肝脏及心肌与肺的比值分别比[（13）N]NH3高10.48倍和2.65倍。与[（13）N]NH3（r = 0.84，P < 0.01）相比，[（18）F]FPTP测量的心肌缺损大小与通过定量2,3,5 - 三苯基四氮唑氯化物染色测量的灌注不足区域相关性更紧密（r = 0.89，P < 0.01）。在心脏PET/CT应用中[（18）F]FPTP可能可用作心肌剂[（13）N]NH3的替代品。
