Kaznessis Yiannis N
Department of Chemical Engineering and Materials Science University of Minnesota, Minneapolis, MN 55455, USA
Curr Opin Chem Eng. 2014 Nov 1;6:18-24. doi: 10.1016/j.coche.2014.08.002.
The discovery of antibiotics is one of the most important advances in the history of humankind. For eighty years human life expectancy and standards of living improved greatly thanks to antibiotics. But bacteria have been fighting back, developing resistance to our most potent molecules. New, alternative strategies must be explored as antibiotic therapies become obsolete because of bacterial resistance. Mathematical models and simulations guide the development of complex technologies, such as aircrafts, bridges, communication systems and transportation systems. Herein, models are discussed that guide the development of new antibiotic technologies. These models span multiple molecular and cellular scales, and facilitate the development of a technology that addresses a significant societal challenge. We argue that simulations can be a creative source of knowledge.
抗生素的发现是人类历史上最重要的进展之一。八十年来，得益于抗生素，人类预期寿命和生活水平得到了极大提高。但细菌一直在反击，对我们最有效的分子产生了耐药性。由于细菌耐药性，抗生素疗法变得过时，因此必须探索新的替代策略。数学模型和模拟指导着复杂技术的发展，如飞机、桥梁、通信系统和运输系统。在此，将讨论指导新型抗生素技术发展的模型。这些模型跨越多个分子和细胞尺度，并促进了一项应对重大社会挑战的技术的发展。我们认为模拟可以成为知识的创造性来源。
