Centre for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, UNSW Australia, Sydney, New South Wales 2052, Australia.
ACS Infect Dis. 2021 Feb 12;7(2):215-253. doi: 10.1021/acsinfecdis.0c00635. Epub 2021 Jan 12.
Antibiotic resistance is a critical global healthcare issue that urgently needs new effective solutions. While small molecule antibiotics have been safeguarding us for nearly a century since the discovery of penicillin by Alexander Fleming, the emergence of a new class of antimicrobials in the form of synthetic antimicrobial polymers, which was driven by the advances in controlled polymerization techniques and the desire to mimic naturally occurring antimicrobial peptides, could play a key role in fighting multidrug resistant bacteria in the near future. By harnessing the ability to control chemical and structural properties of polymers almost at will, synthetic antimicrobial polymers can be strategically utilized in combination therapy with various antimicrobial coagents in different formats to yield more potent (synergistic) outcomes. In this review, we present a short summary of the different combination therapies involving synthetic antimicrobial polymers, focusing on their combinations with nitric oxide, antibiotics, essential oils, and metal- and carbon-based inorganics.
抗生素耐药性是一个全球性的医疗保健难题，迫切需要新的有效解决方案。自亚历山大·弗莱明发现青霉素以来，小分子抗生素已经保护了我们近一个世纪，而以合成抗菌聚合物形式出现的新型抗菌药物，受到控制聚合技术进步和模仿天然存在的抗菌肽的愿望的推动，在不久的将来可能在对抗多药耐药菌方面发挥关键作用。通过利用几乎随心所欲地控制聚合物化学和结构特性的能力，合成抗菌聚合物可以与不同形式的各种抗菌凝结剂联合使用进行策略性的组合治疗，从而产生更有效的（协同）结果。在这篇综述中，我们简要总结了涉及合成抗菌聚合物的不同组合疗法，重点介绍了它们与一氧化氮、抗生素、精油以及金属和基于碳的无机物的组合。
