Rübsamen-Waigmann H
Offentl Gesundheitswes. 1989 Aug-Sep;51(8-9):562-6.
Previous work had shown that HIV-1 is a large group of highly divergent viruses, which mutate quickly in the infected person. The analysis of two HIV-2 strains by molecular cloning and sequence analysis has now proved that HIV-2 is a large and very divergent family of viruses as well and that genetically different subtypes exist in the same individual. Both, HIV-1 and HIV-2 strains form subtypes with remarkable differences in their growth potential on lymphocytes and macrophages. Such properties may change during the persistent infection. An antiviral chemotherapy thus must be active against HIV-1 and HIV-2, it must inhibit the viruses on lymphocytes as well as on macrophages and should begin early, in order to avoid that new HIV-subtypes arise in the patient.
先前的研究表明，HIV-1是一大组高度分化的病毒，在感染者体内会迅速变异。现在，通过分子克隆和序列分析对两株HIV-2毒株进行的分析证明，HIV-2也是一个庞大且分化极大的病毒家族，并且同一个体内存在基因不同的亚型。HIV-1和HIV-2毒株均形成了亚型，它们在淋巴细胞和巨噬细胞上的生长潜力存在显著差异。这些特性在持续感染过程中可能会发生变化。因此，抗病毒化疗必须对HIV-1和HIV-2均有效，必须抑制淋巴细胞和巨噬细胞上的病毒，并且应该尽早开始，以避免患者体内出现新的HIV亚型。
