Sandstrom P A, Folks T M
Retrovirus Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Bioessays. 1996 May;18(5):343-6. doi: 10.1002/bies.950180502.
To date, the effective management of HIV-1 infection by anti-retroviral drugs has proved remarkably difficult to achieve. This is primarily due to the ease with which HIV-1 becomes resistant to drugs which initially may be very effective at blocking viral replication. In a recent issue of Science, two promising new AIDS treatments were reported. The first described the use of retroviral-type zinc finger structures found in the HIV-1 nucleocapsid protein as targets for antiretroviral drugs. THe second demonstrated the feasibility of the reverse transcriptase inhibitor (R)-9-(2-phosphonylmethoxypropyl) adenine as a postexposure prophylaxis in blocking HIV-1 infection.
迄今为止，事实证明，通过抗逆转录病毒药物有效管理HIV-1感染极为困难。这主要是因为HIV-1很容易对那些最初可能非常有效地阻断病毒复制的药物产生耐药性。在最近一期的《科学》杂志上，报道了两种有前景的新型艾滋病治疗方法。第一种方法描述了将在HIV-1核衣壳蛋白中发现的逆转录病毒型锌指结构用作抗逆转录病毒药物的靶点。第二种方法证明了逆转录酶抑制剂（R）-9-（2-膦酰甲氧基丙基）腺嘌呤作为暴露后预防药物来阻断HIV-1感染的可行性。
