Eivazi-Ziaei Jamal, Esmaili Heidarali
Department of Internal Medicine and Pathology, Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cancer Res Ther. 2014 Jul-Sep;10(3):733-6. doi: 10.4103/0973-1482.136029.
Malignant melanoma has been reported to affect all organs of the human body with the metastasis. Stomach metastases are quite rare in cases of the most commonly reported primaries including, melanoma and breast, and lung carcinomas. This report involves, a 56-year-old man suffering from melanoma of the lower extremity that developed into gastric, pulmonary, and brain metastases. The patient who experienced epigastric pain with suspicious melanoma was referred to undergo endoscopy. A black and white ulcer with dimensions of 1 × 1.5 cm and a mass of 1 × 2 cm mass were found at D1 and lesser curvature. Physical examination revealed a 2 × 3 cm black lesion at his right heel. Pathologic examination provided multiple pieces of creamy soft-tissue measuring 0.3 × 0.2 × 0.1 cm showing pigmented tumor cells in lamina propria. Staining biopsy samples with anti-HMB-45 and Fontana demonstrated a higher degree of positivity in tumor cells. The patient was admitted to the hospital, but unfortunately his general conditions were deteriorated and he developed convulsion and deceased four days after admission.
据报道，恶性黑色素瘤可通过转移累及人体所有器官。在最常见的原发肿瘤（包括黑色素瘤、乳腺癌和肺癌）病例中，胃转移相当罕见。本报告涉及一名56岁男性，患有下肢黑色素瘤，已发展为胃、肺和脑转移。该患者因上腹部疼痛且怀疑患有黑色素瘤而被转诊接受内镜检查。在胃大弯和小弯处发现一个大小为1×1.5厘米的黑白溃疡和一个1×2厘米的肿块。体格检查发现其右脚跟有一个2×3厘米的黑色病变。病理检查提供了多块大小为0.3×0.2×0.1厘米的奶油色软组织，显示固有层中有色素沉着的肿瘤细胞。用抗HMB - 45和Fontana对活检样本进行染色，结果显示肿瘤细胞的阳性程度较高。该患者入院，但不幸的是其一般状况恶化，入院四天后出现抽搐并死亡。
