Lucot J B, Crampton G H
Department of Pharmacology and Toxicology, Wright State University, Dayton, OH.
Pharmacol Biochem Behav. 1989 Jul;33(3):627-31. doi: 10.1016/0091-3057(89)90399-7.
Vomiting was suppressed in cats pretreated with 8-OH-DPAT and then challenged with an emetic stimulus; motion, xylazine or cisplatin. The antiemetic effect is likely due to stimulation of postsynaptic serotonin-1A receptors. The most parsimonious explanation is that it acts at a convergent structure, presumably at or near the vomiting center. If so, 8-OH-DPAT may block emesis elicited by virtually any other stimulus. A supplementary experiment revealed that lorazepam suppressed motion sickness at a dose that produced ataxia, but did not suppress xylazine-induced emesis. These results do not support the possibility that the antiemetic effects of 8-OH-DPAT were the result of anxiolytic activity.
在用8-羟基二苯丙氨酸预处理并随后用催吐刺激物（运动、赛拉嗪或顺铂）激发的猫中，呕吐受到抑制。其止吐作用可能是由于对突触后5-羟色胺-1A受体的刺激。最简洁的解释是它作用于一个汇聚结构，大概是在呕吐中枢或其附近。如果是这样，8-羟基二苯丙氨酸可能会阻断几乎任何其他刺激引起的呕吐。一项补充实验表明，劳拉西泮以产生共济失调的剂量抑制晕动病，但不抑制赛拉嗪引起的呕吐。这些结果不支持8-羟基二苯丙氨酸的止吐作用是抗焦虑活性结果的可能性。
