Department of Psychology, University of Guelph, Guelph, ON, Canada.
Psychopharmacology (Berl). 2011 Jun;215(3):505-12. doi: 10.1007/s00213-010-2157-4. Epub 2011 Jan 18.
The interaction between two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabigerol (CBG), which have been reported to act as a 5-hydroxytryptamine 1A (5-HT(1A)) agonist and antagonist, respectively, was evaluated.
To evaluate the potential of CBG to reverse the anti-nausea, anti-emetic effects of CBD.
In experiment 1, rats were pre-treated with CBG (0.0, 1, 5, and 10 mg/kg, ip), 15 min prior to being treated with CBD (experiment 1a: VEH or 5 mg/kg, ip) or 8-OH-DPAT (experiment 1b: VEH or 0.01 mg/kg, ip). Thirty minutes later, all rats received a pairing of 0.1% saccharin solution and LiCl (20 ml/kg of 0.15 M, ip). Seventy-two hours later, the rats received a drug-free taste reactivity test with saccharin to evaluate the effects of the treatments on the establishment of conditioned gaping reactions (a model of nausea). As well, conditioned saccharin avoidance was measured. In experiment 2, Suncus murinus were injected with CBG (5 mg/kg, ip) or VEH 15 min prior to CBD (5 mg/kg) or VEH and 30 min later were injected with LiCl (60 ml/kg of 0.15 M, i.p.), and the number of vomiting episodes were measured.
CBD (5 mg/kg) suppressed conditioned gaping in rats and vomiting in shrews, which were reversed by pre-treatment with all doses of CBG. CBG also prevented the anti-nausea effects of 8-OH-DPAT.
Interactions between moderate doses of CBG and CBD may oppose one another at the 5-HT(1A) receptor in the regulation of nausea and vomiting.
两种非精神类大麻素，大麻二酚（CBD）和大麻萜酚（CBG），分别被报道为 5-羟色胺 1A（5-HT1A）激动剂和拮抗剂，它们之间的相互作用已被研究。
评估 CBG 逆转 CBD 止吐、止呕作用的潜力。
在实验 1 中，大鼠预先给予 CBG（0.0、1、5 和 10 mg/kg，ip），15 分钟后给予 CBD（实验 1a：VEH 或 5 mg/kg，ip）或 8-OH-DPAT（实验 1b：VEH 或 0.01 mg/kg，ip）。30 分钟后，所有大鼠接受 0.1%蔗糖溶液和氯化锂（20 ml/kg，0.15 M，ip）配对。72 小时后，大鼠接受无药物味觉反应测试，用蔗糖评估治疗对条件性张口反应（恶心模型）建立的影响。此外，还测量了条件性蔗糖回避。在实验 2 中，Suncus murinus 预先给予 CBG（5 mg/kg，ip）或 VEH 15 分钟后给予 CBD（5 mg/kg）或 VEH，30 分钟后给予氯化锂（60 ml/kg，0.15 M，ip），并测量呕吐发作次数。
CBD（5 mg/kg）抑制了大鼠的条件性张口和鼩鼱的呕吐，而所有剂量的 CBG 预处理均可逆转。CBG 还预防了 8-OH-DPAT 的止吐作用。
中等剂量的 CBG 和 CBD 之间的相互作用可能在调节恶心和呕吐方面相互拮抗。
