Flower Jennifer E, Gamble Kathryn C, Stone Michael, Lyons Jeremiah A, Maganti Rajanikanth J, Tuomi Pamela A, Olds June E, Sims Michele A, Gauger Phillip, Tuttle Allison D
J Zoo Wildl Med. 2014 Sep;45(3):620-31. doi: 10.1638/2012-0218R1.1.
Six cases of esophageal squamous cell carcinoma were identified in six captive adult Pacific (Phoca vitulina richardsii; n = 2) and Atlantic (Phoca vitulina concolor; n = 4) harbor seals. These seals presented with intermittent dysphagia, regurgitation, inappetence, and abnormal posturing. Common clinical pathology findings in these seals included azotemia, hyperproteinemia, hyperglobulinemia, and leukocytosis. Gastrointestinal endoscopy commonly revealed an ulcerated mass near the gastroesophageal junction. Each seal was euthanized (n = 3) due to poor prognosis, subsequently died while undergoing an anesthetic procedure (n = 2), or found dead (n = 1). The diagnosis of squamous cell carcinoma was confirmed via biopsy of esophageal mucosa during endoscopy or histopathologic examination of affected tissues after necropsy. On the basis of clinical and postmortem findings, esophageal squamous cell carcinoma should be considered as a differential diagnosis in aged harbor seals exhibiting clinical signs of regurgitation, decreased appetite or anorexia, vomiting, and/or abnormal posturing.
在6只圈养的成年太平洋斑海豹（Phoca vitulina richardsii；n = 2）和大西洋斑海豹（Phoca vitulina concolor；n = 4）中确诊了6例食管鳞状细胞癌。这些海豹出现间歇性吞咽困难、反流、食欲不振和姿势异常。这些海豹常见的临床病理表现包括氮血症、高蛋白血症、高球蛋白血症和白细胞增多。胃肠内窥镜检查通常显示胃食管交界处附近有溃疡肿块。由于预后不良，3只海豹实施了安乐死，2只在麻醉过程中死亡，1只被发现死亡。通过内窥镜检查时食管黏膜活检或尸检后对受影响组织进行组织病理学检查，确诊为鳞状细胞癌。根据临床和死后检查结果，对于出现反流、食欲减退或厌食、呕吐和/或姿势异常等临床症状的老年斑海豹，应将食管鳞状细胞癌作为鉴别诊断之一。
