Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan.
Kinosaki Marine World, Hyogo, Japan.
J Vet Med Sci. 2022 Mar 3;84(3):373-377. doi: 10.1292/jvms.21-0156. Epub 2022 Jan 20.
A 21-year-old female spotted seal (Phoca largha), with a swollen abdomen, had a five-month history of anorexia and vomiting. Ultrasonography revealed an extended mass with central necrotic foci in the right cranial abdomen. Computed tomography revealed an abdominal mass with a low-density central lumen and a pulmonary nodular lesion. Cytology of an abdominal specimen collected through fine-needle aspiration indicated a malignant tumor with round, atypical cells with large nuclei. Three days after diagnosis, necropsy revealed a 10-cm large, solid, whitish mass in the pancreatic parenchyma and multiple small nodules in the liver, spleen, mesentery, lungs, and mediastinal lymph nodes. Histopathological analysis showed prolific neoplastic cells with marked atypia and occasional keratinization. Immunohistochemistry revealed that the neoplastic cells were positive for cytokeratin AE1/AE3 antibody. Thus, the seal was diagnosed with squamous cell carcinoma, of presumed pancreatic origin, which had metastasized to multiple organs.
一只 21 岁的雌性斑点海豹（Phoca largha），腹部肿胀，有五个月的厌食和呕吐史。超声检查显示右颅腹部有一个扩展的肿块，中央有坏死灶。计算机断层扫描显示腹部肿块中央有低密度腔和肺结节状病变。通过细针抽吸收集的腹部标本的细胞学检查表明存在恶性肿瘤，具有圆形、非典型的大细胞核细胞。诊断后 3 天，尸检显示胰腺实质中有一个 10 厘米大的实性、白色肿块，肝脏、脾脏、肠系膜、肺和纵隔淋巴结中有多个小结节。组织病理学分析显示大量具有明显异型性和偶尔角化的肿瘤细胞。免疫组织化学显示肿瘤细胞对细胞角蛋白 AE1/AE3 抗体呈阳性。因此，该海豹被诊断为鳞状细胞癌，推测起源于胰腺，已转移到多个器官。
