Scheel Anne, Beijers Antoinetta J M, Mols Floortje, Faber Catharina G, Vreugdenhil Gerard
Maxima Medisch Centrum, afd. Interne geneeskunde, Veldhoven en Eindhoven.
Ned Tijdschr Geneeskd. 2014;158:A7455.
Peripheral neuropathy is a frequently occurring side-effect of chemotherapy as a cancer treatment. The incidence of chemotherapy-induced peripheral neuropathy (CIPN) is increasing as a consequence of better treatment of cancer becoming available and increasing use of chemotherapy, and because CIPN occurs more frequently with use of new chemotherapeutics. The diagnosis 'CIPN' is made principally on clinical grounds, and it is characterized by predominantly sensory symptoms. The National Cancer Institute Common Toxicity Criteria (NCI-CTC) are commonly used to grade CIPN, but the reliability of these criteria is debated. If CIPN occurs, the only effective strategies are dose reduction or discontinuation of chemotherapy. CIPN impairs quality of life. It is important to evaluate the symptoms of CIPN, as well as the impact on daily living.
周围神经病变是癌症化疗常见的副作用。随着癌症治疗手段的改善以及化疗使用的增加，化疗引起的周围神经病变（CIPN）的发生率正在上升，而且由于新化疗药物的使用使得CIPN更为频繁地出现。“CIPN”的诊断主要基于临床依据，其特征主要为感觉症状。美国国立癌症研究所通用毒性标准（NCI-CTC）常用于对CIPN进行分级，但这些标准的可靠性存在争议。如果发生CIPN，唯一有效的策略是减少化疗剂量或停止化疗。CIPN会损害生活质量。评估CIPN的症状以及对日常生活的影响非常重要。
