Istenes Ildikó, Nagy Zsolt, Demeter Judit
I. Sz. Belgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary.
Magy Onkol. 2016 Jun 6;60(2):165-75. Epub 2016 Apr 4.
Longer remissions and better overall survival rates can be achieved with the introduction of new, effective treatments and targeted therapies in the past 1-2 decades, however, the incidence of side effects is also increasing parallelly. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and potentially debilitating side effect due to peripheral somatic or autonomic nerve dysfunction. CIPN becomes increasingly important, as it affects patients' quality of life, and it is very often a dose limiting factor with the potential for reduced treatment efficacy. The pathomechanism, diagnosis, prevention and treatment possibilities are described in this review with special attention to the different groups of drugs.
在过去的10到20年里，通过引入新的有效治疗方法和靶向治疗，可以实现更长的缓解期和更好的总体生存率，然而，副作用的发生率也在同步上升。化疗引起的周围神经病变（CIPN）是一种常见且可能使人衰弱的副作用，由周围躯体或自主神经功能障碍引起。CIPN变得越来越重要，因为它会影响患者的生活质量，而且它常常是一个剂量限制因素，有可能降低治疗效果。本综述描述了其发病机制、诊断、预防和治疗可能性，并特别关注不同类别的药物。
