Futuri Solaiman, Donohoe Kelsey, Spaccavento Colette, Yudelman Ian
Department of Hematology and Oncology, Lenox Hill Hospital, New York, New York, USA.
BMJ Case Rep. 2014 Oct 14;2014:bcr2014205240. doi: 10.1136/bcr-2014-205240.
Leiomyosarcoma of the rectum can develop as a late complication in patients with a history of pelvic irradiation. We report the case of a patient who developed rectal leiomyosarcoma 13 years after receiving radiation for treatment of a stage 2 squamous cell cancer of the anus. This was detected on physical examination. Based on a discussion with the patient, we decided to manage conservatively. Overall, leiomyosarcomas constitute 5-12% of radiation-induced sarcomas. Rectal leiomyosarcoma is rare, accounting for 0.1-0.5% of all malignant tumours of the rectum. As radiation therapy plays a major role in the management of anal cancer, it is important that clinicians are aware of the possible development of radiation-induced sarcomas that may occur decades after initial management.
直肠平滑肌肉瘤可作为盆腔放疗患者的晚期并发症出现。我们报告了一例患者，该患者在接受放疗治疗二期肛门鳞状细胞癌13年后发生了直肠平滑肌肉瘤。这是在体格检查时发现的。经与患者讨论，我们决定采取保守治疗。总体而言，平滑肌肉瘤占放射诱发肉瘤的5%-12%。直肠平滑肌肉瘤罕见，占直肠所有恶性肿瘤的0.1%-0.5%。由于放射治疗在肛门癌的治疗中起主要作用，临床医生认识到在初始治疗数十年后可能发生放射诱发肉瘤很重要。
