迷走神经活动的昼夜节律对哮喘患者支气管运动张力的影响。
The effect of the circadian rhythm of vagal activity on bronchomotor tone in asthma.
作者信息
Morrison J F, Pearson S B
机构信息
Respiratory Function Laboratory, Killingbeck Hospital, Leeds.
出版信息
Br J Clin Pharmacol. 1989 Nov;28(5):545-9. doi: 10.1111/j.1365-2125.1989.tb03540.x.
Abstract
- The effect of the diurnal activity of the parasympathetic nervous system on bronchomotor tone and heart rate was studied in seven asthmatics with nocturnal asthma using both intravenous atropine and nebulised ipratropium at 04.00 h and 16.00 h. 2. A diurnal variation in vagal activity was demonstrated with higher vagal activity occurring at night. 3. There was a strong correlation between the initial response of both airway calibre and heart rate to vagal block both at 04.00 h and 16.00 h. However the duration of bronchodilation after vagal block was greater than with the heart rate suggesting differing sensitivities of pulmonary and cardiac muscarinic receptors to anticholinergic antagonists. 4. The bronchodilation seen after ipratropium was less than that after atropine suggesting that the intravenous route is preferable to study the physiological effect of vagal block in vivo.
摘要
- 利用静脉注射阿托品和雾化吸入异丙托溴铵，于凌晨4点和下午4点，对7名患有夜间哮喘的哮喘患者进行研究，以探讨副交感神经系统昼夜活动对支气管运动张力和心率的影响。2. 证实了迷走神经活动存在昼夜变化，夜间迷走神经活动较高。3. 在凌晨4点和下午4点时，气道口径和心率对迷走神经阻滞的初始反应之间存在很强的相关性。然而，迷走神经阻滞后支气管扩张的持续时间比心率的持续时间更长，这表明肺和心脏毒蕈碱受体对抗胆碱能拮抗剂的敏感性不同。4. 异丙托溴铵后的支气管扩张程度小于阿托品后的支气管扩张程度，这表明静脉途径更适合在体内研究迷走神经阻滞的生理效应。
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