特非那定阻断H1受体对夜间哮喘的影响。
Effects of H1-receptor blockade with terfenadine in nocturnal asthma.
作者信息
Teale C, Morrison J F, Pearson S B
机构信息
Pulmonary Function Laboratory, Killingbeck Hospital, Leeds.
出版信息
Br J Clin Pharmacol. 1991 Sep;32(3):371-3. doi: 10.1111/j.1365-2125.1991.tb03914.x.
Abstract
- In a single-blind placebo controlled study we have measured peak flow (PEFR) at 04.00 h and 16.00 h in eight asthmatics 6 h after placebo or terfenadine 120 mg, to determine if diurnal variation in histamine mediated effects contribute to nocturnal bronchoconstriction in asthma. 2. On placebo there was a significant diurnal variation in mean PEFR of 41 l min-1 (P less than 0.05). Terfenadine improved 04.00 h baseline mean PEFR from 242 to 278 l min-1 (P less than 0.05) but a 38 l min-1 diurnal variation in mean PEFR persisted (P less than 0.05). 3. We conclude that H1-receptor blockade with terfenadine may produce modest nocturnal bronchodilatation but does not influence the diurnal variation in PEFR in asthma suggesting that H1-receptor mediated effects are not important in the pathogenesis of nocturnal asthma.
摘要
- 在一项单盲安慰剂对照研究中，我们在8名哮喘患者服用安慰剂或120毫克特非那定6小时后的04:00和16:00测量了呼气峰值流速（PEFR），以确定组胺介导效应的昼夜变化是否导致哮喘患者夜间支气管收缩。2. 服用安慰剂时，平均PEFR有显著的昼夜变化，为41升/分钟（P<0.05）。特非那定将04:00的基线平均PEFR从242升/分钟提高到278升/分钟（P<0.05），但平均PEFR仍有38升/分钟的昼夜变化（P<0.05）。3. 我们得出结论，特非那定阻断H1受体可能会产生适度的夜间支气管扩张，但不影响哮喘患者PEFR的昼夜变化，这表明H1受体介导的效应在夜间哮喘的发病机制中并不重要。
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