哮喘和慢性阻塞性肺疾病中的肺血管变化。

Pulmonary vascular changes in asthma and COPD.

作者信息

Harkness Louise M, Kanabar Varsha, Sharma Hari S, Westergren-Thorsson Gunilla, Larsson-Callerfelt Anna-Karin

机构信息

Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.

Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, United Kingdom.

出版信息

Pulm Pharmacol Ther. 2014 Dec;29(2):144-55. doi: 10.1016/j.pupt.2014.09.003. Epub 2014 Oct 12.

DOI:10.1016/j.pupt.2014.09.003

PMID:25316209

Abstract

In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.

摘要

在诸如哮喘和慢性阻塞性肺疾病（COPD）等慢性肺部疾病中，支气管血管生成增加，肺血管重塑，最终导致支气管和肺循环改变。内皮细胞、平滑肌细胞和肺成纤维细胞等驻留细胞的参与，似乎在血管炎症和重塑的进展中都起着关键作用。本综述描述了与哮喘和COPD患者肺血管变化相关的调节异常、生长因子和介质以及潜在的治疗靶点。